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Table 2 Predictive efficiency of continuous risk factors for developing ARDS

From: Novel risk scoring system for predicting acute respiratory distress syndrome among hospitalized patients with coronavirus disease 2019 in Wuhan, China

Variables

Youden Index

Cut-off criterion

Sensitivity

Specificity

+LR

-LR

AUC (95%CI)

Age (years)

0.419

≥ 65

67.57%

74.36%

2.64

0.44

0.725 (0.647–0.793)

White blood cell (×109/L)

0.363

> 6.10

59.46%

76.92%

2.58

0.53

0.714 (0.635–0.783)

Lymphocyte (× 109/L)

0.496

≤0.71

67.57%

82.05%

3.76

0.40

0.766 (0.691–0.830)

ALT (U/L)

0.332

≥ 30

81.08%

52.14%

1.69

0.36

0.676 (0.596–0.749)

AST (U/L)

0.423

≥ 37

75.68%

66.67%

2.27

0.36

0.772 (0.697–0.835)

LDH (U/L)

0.597

≥ 295.0

83.78%

75.86%

3.47

0.21

0.860 (0.795–0.911)

Albumin (g/L)

0.304

< 28.5

43.24%

87.18%

3.37

0.65

0.685 (0.605–0.757)

Creatinine (μ mol/L)

0.340

≥ 88.0

45.95%

88.03%

3.84

0.61

0.659 (0.579–0.734)

BUN (mmol/L)

0.479

> 5.12

67.57%

80.34%

3.44

0.40

0.763 (0.688–0.828)

CK-MB (ng/mL)

0.498

> 0.70

77.78%

72.00%

2.78

0.31

0.803 (0.726–0.866)

Troponin I (ng/L)

0.507

> 4.70

88.89%

61.76%

2.32

0.18

0.821 (0.746–0.881)

Prothrombin time (s)

0.209

> 14.20

37.84%

83.04%

2.23

0.75

0.618 (0.535–0.697)

D-Dimer (μ g/ml)

0.307

≥ 5.00

32.43%

98.21%

18.16

0.69

0.691 (0.611–0.764)

C-Reactive protein (mg/L)

0.639

≥ 38.00

86.49%

77.39%

3.83

0.17

0.852 (0.785–0.904)

ESR (mm/h)

0.294

≥60.0

63.89%

65.52%

1.85

0.55

0.611 (0.529–0.689)

Procalcitonin (ng/ml)

0.581

> 0.11

83.78%

74.31%

3.26

0.22

0.854 (0.787–0.907)

Ferritin (ng/ml)

0.602

≥ 950.00

69.44%

90.74%

7.50

0.34

0.872 (0.806–0.921)

  1. *p-value< 0.05
  2. **p-value< 0.01
  3. ***p-value< 0.001