Fig. 4

Biopsy type, histopathological diagnosis and HPV DNA result in lesion for women who had undergone surgical therapy for cervical disease. Case 1: the subject was HPV-16, 52 DNA positive, with ASCUS predicted by cytology at gynecological examination at visit 1. Case 2: occurred in a woman who, at baseline (visit1), was HPV-16 DNA positive, with HSIL predicted by cytology. Case 3: the woman was HPV-16, 59 DNA positive, with LSIL predicted by cytology at visit 1.And the subject was high-risk HPV DNA negative at month 18. HPV-39 was detected at month 30. Case 4: the subject was HPV-16, 31, 33 DNA positive, with HSIL predicted by cytology at gynecological examination at month 6. Case 5: the subject was HPV-58 DNA positive, with LSIL predicted by cytology at gynecological examination at month 66. Abbreviations: CIN: cervical intraepithelial neoplasia; VAIN: vaginal intraepithelial neoplasia; LEEP: loop electrosurgical excision procedure