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Table 1 The characteristics of the included studies

From: The diagnostic accuracy of direct agglutination test for serodiagnosis of human visceral leishmaniasis: a systematic review with meta-analysis

Author Country Year Sample size Diagnostic method Cut off Prasite DAT + Parasitology+ DAT + Parasitology- DAT-Parasitology + DAT-Parasitology - QUADAS score
Bimal [15] India 2005 799 Bone marrow and spleen aspiration ≥1:800 L.donovani 99 0 9 691 12
Silva [16] Brazil 2005 16 Bone marrow aspiration ≥1:800 L.donovani 16 0 0 0 11
Sundar [17] India 2006 329 Spleen aspiration ≥1:3200 ND 227 3 5 94 13
Sundar [18]e India 2006 508 Spleen aspiration ≥1:1600 ND 144 54 6 304 13
Sundar [18]f India 2006 508 Spleen aspiration ≥1:1600 ND 146 45 4 313 13
Kumar [18] India 2006 548 Bone marrow and spleen aspiration ≥1:800 L.donovani 63 4 17 464 10
El Mutasim [19] Sudan 2004–2005 302 Lymph nodes, bonemarrow or spleen aspiration ≥1:3200 L.donovani 92 16 7 187 13
Gavgani [20] Iran 2007 12 Bone marrow aspiration ≥1:3200 L.infantum 12 0 0 0 9
Mansour [21] Sudan 2004–2006 174 Lymph node aspirate ≥1:3200 L.donovani 24 1 1 148 11
Teran-Angel [22] Venezuela 2007 54 Bone marrow or spleen aspiration > 1:1:600 L.donovani 26 0 0 28 10
Taran [23] Iran 2004–2006 15 Bone marrow aspiration ≥1:3200 L.infantum 12 3 0 0 12
Sinha [24] a India 2008 18 Spleen or bone marrow aspiration ≥1:800 L.donovani 6 2 0 10 11
Sinha [24] b India 2008 20 Spleen or bone marrow aspiration ≥1:800 L.donovani 10 0 0 10 11
Kilic [25] Turkey 2008 59 Bone marrow aspiration - culture ≥1:1600 L.donovani 24 4 0 31 12
Mandal [26] India 2005–2006 57 Spleen and bone marrow aspiration ≥1:800 L.donovani 16 1 0 40 10
Ghatei [27] Iran 2005–2009 90 Bone marrow or spleen aspiration ≥1:3200 L.infantum 27 0 2 61 12
Hailu [28] Ethiopia 2006 137 Spleen or lymph node aspiration - cultures ≥1:1600 ND 41 20 43 33 10
Mansour [29] Sudan 2004–2005 322 Lymph node aspirate ≥1:3200 L.donovani 114 17 11 180 11
Ter Horst [30] Ethiopia 2006–2007 699 Spleen aspiration ≥1:3200 L.donovani 144 338 9 208 10
Gani [31] Iraq 2004–2006 57 Bone marrow aspiration ≥1:800 ND 10 0 47 0 11
Topno [32] India 2005 355 Bone marrow or spleen aspiration ≥1:800 L.donovani 5 34 0 316 12
Abass [33] Sudan 2011 183 Lymph node aspiration ≥1:3200 L.donovani 100 6 0 77 11
El. Moamly [34] c Saudi Arabia 2004–2006 33 Bone marrow aspiration - culture ≥1:1600 L.donovani 9 1 1 22 12
El. Moamly [34] d Saudi Arabia 2004–2006 65 Bone marrow aspiration - culture ≥1:1600 L.donovani 24 2 1 38 12
Machado [35] Brazil 2004–2007 356 Bone marrow smear ≥1:3200 L.infantum 192 41 21 102 8
Junior [36] Brazil 2015 7 Bone marrow aspiration ≥1:3200 L.infantum 3 4 0 0 10
Osman [37]g Sudan 2016 135 Lymph node aspirate ≥1:3200 L.donovani 92 0 1 42 11
Osman [37]h Sudan 2016 141 Lymph node aspirate ≥1:3200 L.donovani 95 0 4 42 11
  1. aCoinfection of VL in HIV+patients
  2. bVL in immunocompatent patients
  3. cSudanese VL patients
  4. dAsian VL patients
  5. eFreezed Dried DAT(FD) antigen
  6. fAqueous DAT antigen (AQ)
  7. gFreezed Dried (FD) DAT antigen
  8. hLiquid (LQ) DAT antigen