The diagnostic accuracy of direct agglutination test for serodiagnosis of human visceral leishmaniasis: a systematic review with meta-analysis

Mohebali, Mehdi; Keshavarz, Hossein; Shirmohammad, Sedigheh; Akhoundi, Behnaz; Borjian, Alireza; Hassanpour, Gholamreza; Mamishi, Setareh; Mahmoudi, Shima

doi:10.1186/s12879-020-05558-7

Table 1 The characteristics of the included studies

From: The diagnostic accuracy of direct agglutination test for serodiagnosis of human visceral leishmaniasis: a systematic review with meta-analysis

Author	Country	Year	Sample size	Diagnostic method	Cut off	Prasite	DAT + Parasitology+	DAT + Parasitology-	DAT-Parasitology +	DAT-Parasitology -	QUADAS score
Bimal [15]	India	2005	799	Bone marrow and spleen aspiration	≥1:800	L.donovani	99	0	9	691	12
Silva [16]	Brazil	2005	16	Bone marrow aspiration	≥1:800	L.donovani	16	0	0	0	11
Sundar [17]	India	2006	329	Spleen aspiration	≥1:3200	ND	227	3	5	94	13
Sundar [18]^e	India	2006	508	Spleen aspiration	≥1:1600	ND	144	54	6	304	13
Sundar [18]^f	India	2006	508	Spleen aspiration	≥1:1600	ND	146	45	4	313	13
Kumar [18]	India	2006	548	Bone marrow and spleen aspiration	≥1:800	L.donovani	63	4	17	464	10
El Mutasim [19]	Sudan	2004–2005	302	Lymph nodes, bonemarrow or spleen aspiration	≥1:3200	L.donovani	92	16	7	187	13
Gavgani [20]	Iran	2007	12	Bone marrow aspiration	≥1:3200	L.infantum	12	0	0	0	9
Mansour [21]	Sudan	2004–2006	174	Lymph node aspirate	≥1:3200	L.donovani	24	1	1	148	11
Teran-Angel [22]	Venezuela	2007	54	Bone marrow or spleen aspiration	> 1:1:600	L.donovani	26	0	0	28	10
Taran [23]	Iran	2004–2006	15	Bone marrow aspiration	≥1:3200	L.infantum	12	3	0	0	12
Sinha [24] ^a	India	2008	18	Spleen or bone marrow aspiration	≥1:800	L.donovani	6	2	0	10	11
Sinha [24] ^b	India	2008	20	Spleen or bone marrow aspiration	≥1:800	L.donovani	10	0	0	10	11
Kilic [25]	Turkey	2008	59	Bone marrow aspiration - culture	≥1:1600	L.donovani	24	4	0	31	12
Mandal [26]	India	2005–2006	57	Spleen and bone marrow aspiration	≥1:800	L.donovani	16	1	0	40	10
Ghatei [27]	Iran	2005–2009	90	Bone marrow or spleen aspiration	≥1:3200	L.infantum	27	0	2	61	12
Hailu [28]	Ethiopia	2006	137	Spleen or lymph node aspiration - cultures	≥1:1600	ND	41	20	43	33	10
Mansour [29]	Sudan	2004–2005	322	Lymph node aspirate	≥1:3200	L.donovani	114	17	11	180	11
Ter Horst [30]	Ethiopia	2006–2007	699	Spleen aspiration	≥1:3200	L.donovani	144	338	9	208	10
Gani [31]	Iraq	2004–2006	57	Bone marrow aspiration	≥1:800	ND	10	0	47	0	11
Topno [32]	India	2005	355	Bone marrow or spleen aspiration	≥1:800	L.donovani	5	34	0	316	12
Abass [33]	Sudan	2011	183	Lymph node aspiration	≥1:3200	L.donovani	100	6	0	77	11
El. Moamly [34] ^c	Saudi Arabia	2004–2006	33	Bone marrow aspiration - culture	≥1:1600	L.donovani	9	1	1	22	12
El. Moamly [34] ^d	Saudi Arabia	2004–2006	65	Bone marrow aspiration - culture	≥1:1600	L.donovani	24	2	1	38	12
Machado [35]	Brazil	2004–2007	356	Bone marrow smear	≥1:3200	L.infantum	192	41	21	102	8
Junior [36]	Brazil	2015	7	Bone marrow aspiration	≥1:3200	L.infantum	3	4	0	0	10
Osman [37]^g	Sudan	2016	135	Lymph node aspirate	≥1:3200	L.donovani	92	0	1	42	11
Osman [37]^h	Sudan	2016	141	Lymph node aspirate	≥1:3200	L.donovani	95	0	4	42	11

^aCoinfection of VL in HIV+patients
^bVL in immunocompatent patients
^cSudanese VL patients
^dAsian VL patients
^eFreezed Dried DAT(FD) antigen
^fAqueous DAT antigen (AQ)
^gFreezed Dried (FD) DAT antigen
^hLiquid (LQ) DAT antigen

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ISSN: 1471-2334

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