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Table 2 Course of illness, main laboratory indexes and treatment of the death group and nondeath group

From: Risk factors associated with death in infants <120 days old with severe pertussis: a case-control study

Characteristic

Deaths (n = 15)

Nondeaths (n = 44)

 

NO. of Patients

NO. (%)

NO. of Patients

NO. (%)

P Value

Course of illness

 length of hospital stay (IQR)

 

10 (3–15)

 

25.5 (19.25–31.75)

0

 Cough duration before the PICU (IQR)

 

11 (7–14)

 

14 (8–19.75)

0.061

 length of PICU stay (IQR)

 

3 (2–12)

 

13.5 (8–17)

0.003

 Leukocytosis (WBC ≥ 30 × 109 /L.)

14

93.33%

19

43.18%

0.001

 Leukocytosis (WBC ≥ 50 × 109 /L.)

13

86.67%

7

15.91%

0

 Highest WBC count

 

77.33 ± 28.56

 

30.52 ± 16.46

0

 Highest lymphocyte count

 

29.59 ± 13.59

 

16.19 ± 9.20

0

 Highest Platelet count

 

740.47 ± 199.93

 

696.05 ± 153.47

0.375

 Congenital heart disease (ASD or PDA)

5 (13)

38.46%

15 (36)

41.66%

1

 Pulmonary hypertension

8 (14)

57.14%

3 (36)

8.33%

0.001

 Pulmonary hypertension without CHD

3 (8)

44.40%

0 (3)

0

0.214

 Pneumonia

15

100%

44

100%

 

 Co-infectious with clearly pathogen

13

86.60%

38

86.36%

0.976

 Consolidation of lung

9

60.00%

23

52.27%

0.604

 Convulsions

2

13.30%

8

18.20%

0.666

 Pertussis encephalopathy

5

33.30%

21

47.70%

0.332

 Co- morbidity

12

80.00%

24

54.54%

0.081

Treatment

 Received macrolide antibiotics

15

100%

44

100%

 

 Days to macrolide initiation (IQR)

 

8 (6–11)

 

10.5 (9–15)

0.012

 Received steroids

6

40.00%

13

29.50%

0.454

 Respiratory support (invasive or/and noninvasive)

15

100%

36 + 4

90.90%

0.226

 intubated

15

100%

36

81.80%

0.076

 Ventilator time

 

3 (2–12)

 

8 (5–13.75)

0.412

 Exchange transfusion

3

20.00%

2

4.55%

0.063

 ECMO

1

0.07%

0

 

0.084

  1. Abbreviations: IQR interquartile range, CHD congenital heart disease, ECMO extracorporeal membrane oxygenation, ASD atrial septal defect, PDA patent ductus arteriosus
  2. Leukocytosis was defined as WBC count ≥30 × 109 /L
  3. Co-morbidity included CHD, bronchopulmonary dysplasia, hypoxic ischaemic encephalopathy, rotavirus enteritis, Down syndrome, hypoplasia of the laryngeal cartilage, adenovirus encephalitis, and epilepsy