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Table 2 Course of illness, main laboratory indexes and treatment of the death group and nondeath group

From: Risk factors associated with death in infants <120 days old with severe pertussis: a case-control study

Characteristic Deaths (n = 15) Nondeaths (n = 44)  
NO. of Patients NO. (%) NO. of Patients NO. (%) P Value
Course of illness
 length of hospital stay (IQR)   10 (3–15)   25.5 (19.25–31.75) 0
 Cough duration before the PICU (IQR)   11 (7–14)   14 (8–19.75) 0.061
 length of PICU stay (IQR)   3 (2–12)   13.5 (8–17) 0.003
 Leukocytosis (WBC ≥ 30 × 109 /L.) 14 93.33% 19 43.18% 0.001
 Leukocytosis (WBC ≥ 50 × 109 /L.) 13 86.67% 7 15.91% 0
 Highest WBC count   77.33 ± 28.56   30.52 ± 16.46 0
 Highest lymphocyte count   29.59 ± 13.59   16.19 ± 9.20 0
 Highest Platelet count   740.47 ± 199.93   696.05 ± 153.47 0.375
 Congenital heart disease (ASD or PDA) 5 (13) 38.46% 15 (36) 41.66% 1
 Pulmonary hypertension 8 (14) 57.14% 3 (36) 8.33% 0.001
 Pulmonary hypertension without CHD 3 (8) 44.40% 0 (3) 0 0.214
 Pneumonia 15 100% 44 100%  
 Co-infectious with clearly pathogen 13 86.60% 38 86.36% 0.976
 Consolidation of lung 9 60.00% 23 52.27% 0.604
 Convulsions 2 13.30% 8 18.20% 0.666
 Pertussis encephalopathy 5 33.30% 21 47.70% 0.332
 Co- morbidity 12 80.00% 24 54.54% 0.081
Treatment
 Received macrolide antibiotics 15 100% 44 100%  
 Days to macrolide initiation (IQR)   8 (6–11)   10.5 (9–15) 0.012
 Received steroids 6 40.00% 13 29.50% 0.454
 Respiratory support (invasive or/and noninvasive) 15 100% 36 + 4 90.90% 0.226
 intubated 15 100% 36 81.80% 0.076
 Ventilator time   3 (2–12)   8 (5–13.75) 0.412
 Exchange transfusion 3 20.00% 2 4.55% 0.063
 ECMO 1 0.07% 0   0.084
  1. Abbreviations: IQR interquartile range, CHD congenital heart disease, ECMO extracorporeal membrane oxygenation, ASD atrial septal defect, PDA patent ductus arteriosus
  2. Leukocytosis was defined as WBC count ≥30 × 109 /L
  3. Co-morbidity included CHD, bronchopulmonary dysplasia, hypoxic ischaemic encephalopathy, rotavirus enteritis, Down syndrome, hypoplasia of the laryngeal cartilage, adenovirus encephalitis, and epilepsy