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Fig. 5 | BMC Infectious Diseases

Fig. 5

From: Bone marrow-derived mesenchymal stem cells attenuate pulmonary inflammation and lung damage caused by highly pathogenic avian influenza A/H5N1 virus in BALB/c mice

Fig. 5

MSCs lowered the level of histological lung injury. a Comparison of histopathology for lung tissues by HE staining between MSC- and mock-treated groups. Alveolar edema (green arrows), alveolar inflammation and interstitial tissue (yellow arrows), alveolar bleeding and interstitial tissue (blue arrows), and atelectasis (black arrows) were observed under a light microscopy with a X400 magnification. b Comparison of histopathological scores between MSC- and mock-treated groups. Edema, alveolar inflammation, interstitial inflammation, alveolar hemorrhage, interstitial hemorrhage, atelectasis, necrosis and formation of hyaline membranes were individually scored (0 to 4) and the sum of the 7 scores represented the lung injury score (0 to28). Examining 5 viewing fields of each tissue section determined the score of one lung. Data shown are means ± SD of six mice in each group. ● indicates significant difference (P < 0.05) between two groups. d pi: days post-inoculation

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BMC Infectious Diseases

ISSN: 1471-2334

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