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Fig. 3 | BMC Infectious Diseases

Fig. 3

From: Bone marrow-derived mesenchymal stem cells attenuate pulmonary inflammation and lung damage caused by highly pathogenic avian influenza A/H5N1 virus in BALB/c mice

Fig. 3

Homing of the administrated MSCs to the lung. The PKH26-labeled MSCs were intravenously administrated via tail vein to mice infected with A/H5N1 virus on day 2 and the mouse lung tissues were examined on day 3 for MSCs homing by detecting fluorescence under the microscope. a With MSC administration, the red fluorescence was observed in the entire field of view in the left panel and yellowish green fluorescence in the right panel of merged image, indicating presence of the homing all over the lung. Light blue arrows indicate typical positive spots for yellowish green fluorescence. b With control PBS administration, neither red nor yellowish green fluorescence was observed. c With MSC administration to normal mice without the virus infection, the red fluorescence was observed in the localized places in the left panel and yellowish green fluorescence localized only on the edges of blood vessels in the right panel of merge image, indicating the absence of MSC homing to the lung tissue. Left panels: PKH26 red fluorescence, center panels: green autofluorescence, and right panels: the merged image of the two

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