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Table 2 Factors associated with MTCT of HIV in two areas of China, 2004–2018 (N = 899)

From: Preventing mother to child transmission of HIV: lessons learned from China

  AORa (95% CI) P AORb (95% CI) P
Maternal age (years)
  ≤ 27 1   1  
  > 27 0.96 (0.54, 1.71) 0.894 0.89 (0.47, 1.66) 0.696
Ethnicity
 Han 1   1  
 Uygur 0.38 (0.03, 4.36) 0.413 0.38 (0.03, 4.58) 0.423
 Others 0.69 (0.09, 5.09) 0.702 0.69 (0.09, 5.27) 0.706
Route of infection
 Sex 1   1  
 Others 1.13 (0.36, 3.58) 0.818 1.14 (0.34, 3.82) 0.825
HIV status of sexual partner
 Negative 1   1  
 Positive 1.15 (0.60, 2.21) 0.671 1.16 (0.60, 2.24) 0.649
 Unknown 0.77 (0.22, 2.63) 0.664 0.83 (0.23, 3.01) 0.765
Multipara or not
 Yes 1.17 (0.64, 2.16) 0.594 1.19 (0.61, 2.30) 0.598
 No 1   1  
Sex of infant
 Female 1   1  
 Male 1.10 (0.62, 1.97) 0.736 1.12 (0.62, 2.00) 0.703
 Unknown 0.74 (0.19, 2.94) 0.661 0.88 (0.20, 3.79) 0.858
ARVs for pregnant women
 Yes 0.14 (0.07, 0.27) < 0.001 0.11 (0.06, 0.23) < 0.001
 No 1   1  
Regimens of ARVs for mothers
 Prenatal cART 1   1  
 AZT alone 12.87 (1.18, 140.65) 0.037 11.35 (1.03, 124.80) 0.047
 sdARVs 14.23 (1.61, 126.12) 0.018 13.27 (1.48, 118.83) 0.022
 No ARVs 56.02 (7.01, 447.60) < 0.001 62.33 (7.77, 500.15) < 0.001
Intrapartum CD4 count(/μL)
  ≥ 200 1   1  
  < 200 5.21 (2.28, 11.87) < 0.001 5.41 (2.32, 12.61) < 0.001
 Unknown 3.13 (1.42, 6.92) 0.006 3.41 (1.53, 7.59) 0.004
Mode of delivery
 Cesarean section 1   1  
 Vaginal delivery 1.41 (0.76, 2.62) 0.263 1.46 (0.78, 2.75) 0.227
Birth weight
  ≥ 2500 g 1   1  
  < 2500 g 4.93 (2.20, 11.02) < 0.001 5.18 (2.27, 11.81) < 0.001
 Unknown 1.11 (0.44, 2.78) 0.818 1.33 (0.42, 4.15) 0.619
IP
 Yes 1   1  
 No 5.76 (3.04, 10.93) < 0.001 6.74 (3.43, 13.23) < 0.001
Breastfeeding
 Never 1   1  
 Ever 11.14 (5.38, 23.03) < 0.001 12.31 (5.78, 26.20) < 0.001
Complex interventions
 Prenatal cART+IP + FF 1   1  
 AZT alone+IP + FF 13.86 (1.29, 149.25) 0.031 12.21 (1.13, 131.71) 0.040
 sdARVs+IP + FF 16.17 (1.84, 142.00) 0.013 15.05 (1.71, 132.86) 0.015
 IP + FF 34.53 (3.88, 307.51) 0.002 35.81 (4.00, 320.54) 0.002
 Only FF 31.77 (3.74, 270.02) 0.002 35.99 (4.22, 306.99) 0.001
 Non-intervention 162.32 (19.56, 1347.36) < 0.001 179.81 (21.59,1497.57) < 0.001
 Others 39.02 (1.94, 783.13) 0.017 40.21 (1.98,817.95) 0.017
  1. AOR Adjusted odds ratio
  2. AORa were adjusted for area and year of birth
  3. AORb were adjusted for area, year of birth, maternal age (years), ethnicity, route of infection, HIV status of sexual partner, multipara or not, and sex of infant