Table 2 Factors associated with MTCT of HIV in two areas of China, 2004–2018 (N = 899)
From: Preventing mother to child transmission of HIV: lessons learned from China
AORa (95% CI) | P | AORb (95% CI) | P | |
|---|---|---|---|---|
Maternal age (years) | ||||
≤ 27 | 1 | 1 | ||
> 27 | 0.96 (0.54, 1.71) | 0.894 | 0.89 (0.47, 1.66) | 0.696 |
Ethnicity | ||||
Han | 1 | 1 | ||
Uygur | 0.38 (0.03, 4.36) | 0.413 | 0.38 (0.03, 4.58) | 0.423 |
Others | 0.69 (0.09, 5.09) | 0.702 | 0.69 (0.09, 5.27) | 0.706 |
Route of infection | ||||
Sex | 1 | 1 | ||
Others | 1.13 (0.36, 3.58) | 0.818 | 1.14 (0.34, 3.82) | 0.825 |
HIV status of sexual partner | ||||
Negative | 1 | 1 | ||
Positive | 1.15 (0.60, 2.21) | 0.671 | 1.16 (0.60, 2.24) | 0.649 |
Unknown | 0.77 (0.22, 2.63) | 0.664 | 0.83 (0.23, 3.01) | 0.765 |
Multipara or not | ||||
Yes | 1.17 (0.64, 2.16) | 0.594 | 1.19 (0.61, 2.30) | 0.598 |
No | 1 | 1 | ||
Sex of infant | ||||
Female | 1 | 1 | ||
Male | 1.10 (0.62, 1.97) | 0.736 | 1.12 (0.62, 2.00) | 0.703 |
Unknown | 0.74 (0.19, 2.94) | 0.661 | 0.88 (0.20, 3.79) | 0.858 |
ARVs for pregnant women | ||||
Yes | 0.14 (0.07, 0.27) | < 0.001 | 0.11 (0.06, 0.23) | < 0.001 |
No | 1 | 1 | ||
Regimens of ARVs for mothers | ||||
Prenatal cART | 1 | 1 | ||
AZT alone | 12.87 (1.18, 140.65) | 0.037 | 11.35 (1.03, 124.80) | 0.047 |
sdARVs | 14.23 (1.61, 126.12) | 0.018 | 13.27 (1.48, 118.83) | 0.022 |
No ARVs | 56.02 (7.01, 447.60) | < 0.001 | 62.33 (7.77, 500.15) | < 0.001 |
Intrapartum CD4 count(/μL) | ||||
≥ 200 | 1 | 1 | ||
< 200 | 5.21 (2.28, 11.87) | < 0.001 | 5.41 (2.32, 12.61) | < 0.001 |
Unknown | 3.13 (1.42, 6.92) | 0.006 | 3.41 (1.53, 7.59) | 0.004 |
Mode of delivery | ||||
Cesarean section | 1 | 1 | ||
Vaginal delivery | 1.41 (0.76, 2.62) | 0.263 | 1.46 (0.78, 2.75) | 0.227 |
Birth weight | ||||
≥ 2500 g | 1 | 1 | ||
< 2500 g | 4.93 (2.20, 11.02) | < 0.001 | 5.18 (2.27, 11.81) | < 0.001 |
Unknown | 1.11 (0.44, 2.78) | 0.818 | 1.33 (0.42, 4.15) | 0.619 |
IP | ||||
Yes | 1 | 1 | ||
No | 5.76 (3.04, 10.93) | < 0.001 | 6.74 (3.43, 13.23) | < 0.001 |
Breastfeeding | ||||
Never | 1 | 1 | ||
Ever | 11.14 (5.38, 23.03) | < 0.001 | 12.31 (5.78, 26.20) | < 0.001 |
Complex interventions | ||||
Prenatal cART+IP + FF | 1 | 1 | ||
AZT alone+IP + FF | 13.86 (1.29, 149.25) | 0.031 | 12.21 (1.13, 131.71) | 0.040 |
sdARVs+IP + FF | 16.17 (1.84, 142.00) | 0.013 | 15.05 (1.71, 132.86) | 0.015 |
IP + FF | 34.53 (3.88, 307.51) | 0.002 | 35.81 (4.00, 320.54) | 0.002 |
Only FF | 31.77 (3.74, 270.02) | 0.002 | 35.99 (4.22, 306.99) | 0.001 |
Non-intervention | 162.32 (19.56, 1347.36) | < 0.001 | 179.81 (21.59,1497.57) | < 0.001 |
Others | 39.02 (1.94, 783.13) | 0.017 | 40.21 (1.98,817.95) | 0.017 |