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Table 3 Clinical characteristics of Group II patients before VPS and one weeks after VPS

From: Triple therapy combined with ventriculoperitoneal shunts can improve neurological function and shorten hospitalization time in non-HIV cryptococcal meningitis patients with increased intracranial pressure

Patient

Before VPS

one week after VPS

P-value

CSF parametersopening pressure

 ≥ 25 mH2O(n, %)

33 (84.6%)

12 (30.8%)

0.000*

 CSF WBC count×106/l (med, range)

66 (4–620)

77 (0–993)

0.220

 ≥20 (n,%)

36 (80.0%)

41 (91.1%)

0.136

 CSF protein g/l (med, range)

0.67 (0.22–4.08)

2.29 (0.08–729)

0.000*

 CSF glucose mmol/l (med, range)

1.16 (0.01–3.47)

0.91 (0.01–4.86)

0.380

 CSF cryptococci count/ml (med, range)

9533 (0–263,000)

2066 (0–235,000)

0.019*

 CSF culture positive (+) (n, %)

19 (48.7%)

6 (15.4%)

0.002*

BMR staging (n = 39)

  

0.026*

 1

8 (20.5%)

14 (35.9%)

 

 2

10 (25.6%)

14 (35.9%)

 

 3

21 (53.8%)

11 (28.2%)

 

Complications after VSP (n, %)

NA

20 (44.4%)

NA

 Fever 3 days after VPS

NA

16 (35.6%)

NA

 Over-shunting

NA

2 (4.4%)

NA

 Obstructed shunt

NA

3 (6.7%)

NA

 Secondary abdominal infection

NA

1 (2.2%)

NA

  1. VPS ventriculoperitoneal shunts, WBC white blood cell, med median, CSF cerebrospinal fluid, NA not available. Data are presented as median (range) or n (%). Categorical variables were analyzed by Chi-square test or Fisher’s exact test
  2. *P < 0.05