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Table 2 The relationship between study variables and mortality of patients with severe COVID-19

From: The use of intravenous immunoglobulin gamma for the treatment of severe coronavirus disease 2019: a randomized placebo-controlled double-blind clinical trial

  Mortality Unadjusted OR (95% CI) P-value
No Yes
Treatment Group 24 (61.5) 6 (30) 0.27 (0.08, 0.85) 0.025#
Control Group 15 (38.5) 14 (70) Ref  
Age (years) 54 (44, 60) 60 (53.5, 70) 1.05 (1.01, 1.1) 0.014
Gender n (%) Male 27 (70) 14 (70) 0.96 (0.3, 3.12) 0.951
Female 12 (30) 6 (30) Ref  
HTN n (%) 8 (23.3) 5 (25) 1.29 (0.36, 4.63) 0.694
DM n (%) 11 (20) 5 (25) 0.85 (0.25, 2.9) 0.793
Chronic lung disease n (%) 1 (6.6) 1 (5) 2 (0.12, 33.76) 0.630
HR/min 95 (90, 100) 95 (89, 108) 1.02 (0.96, 1.08) 0.543
Systolic BP (mmHg) 120 (120, 130) 120 (110, 130) 0.97 (0.93, 1.01) 0.173
Diastolic BP (mmHg) 80 (70, 80) 70 (70, 80) 0.95 (0.88, 1.01) 0.120
RR /min 19 (18, 22) 20 (18, 22) 0.98 (0.93, 1.04) 0.545
BT C° 37.1 (36.7, 37.7) 37.1 (36.75, 37.65) 1.26 (0.63, 2.52) 0.518
O2 saturation (%) 89 (87, 89) 85 (80, 88) 0.84 (0.74, 0.97) 0.015
WBC (1000/mm3) 5.1 (4.6, 7.4) 7.2 (5.1, 11.2) 1.00 (1.00, 1.00) 0.743
Hb (g/dl) 13.9 (12.6, 15) 13.5 (12.05, 15.25) 0.95 (0.8, 1.13) 0.566
Plt (1000/mm3) 210 (135, 247) 172.5 (139.5, 193) 1.00 (1.00, 1.00) 0.090
LDH (U/L) 520 (400, 687) 761 (560.5, 1021) 1.00 (1.00, 1.00) 0.003
BUN (mg/dl) 29 (25, 39) 64 (50, 129.5) 1.06 (1.02, 1.09) 0.001
Creatinine (mg/dl) 1 (1, 1.2) 1.2 (1.1, 1.55) 3.63 (0.95, 13.87) 0.059
K (mEq/L) 4 (3.7, 4.4) 4.2 (4.1, 4.3) 0.95 (0.8, 1.14) 0.616
Na (mEq/L) 138 (137, 139) 138 (135, 143.5) 1.04 (0.95, 1.14) 0.344
ESR 28 (20, 41) 40 (26, 49.5) 1.01 (0.99, 1.03) 0.424
AST (U/L) 31 (21, 39) 29.5 (15.5, 52.5) 1.00 (0.97, 1.02) 0.735
ALT (U/L) 34.5 (25, 41) 38.5 (29.5, 48) 1.01 (0.99, 1.02) 0.306
BS (mg/dl) 119 (105, 174) 126 (109.5, 184) 1.00 (0.99, 1.01) 0.845
PaO2 (mmHg) 46 (40, 50) 39.5 (34, 49) 0.92 (0.85, 0.99) 0.035
PCO2 (mmHg) 40 (35, 46) 38 (36, 39.5) 0.99 (0.91, 1.08) 0.798
HCO3 (mEq/L) 24 (22, 25) 24.5 (19.5, 26.5) 1.00 (0.89, 1.13) 0.946
pH 7.3 (7.3, 7.4) 7.3 (7.2, 7.4) 0.04 (0, 8.87) 0.243