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Table 1 Evaluated characteristics of patients with severe COVID-19 infection

From: The use of intravenous immunoglobulin gamma for the treatment of severe coronavirus disease 2019: a randomized placebo-controlled double-blind clinical trial

  Total IVIg Group Control Group P-value$
Age (years)a 56 (46,62) 55.5 (45,60) 56 (47,66) 0.375
Sex n (%)
Male 41 (69.5) 21 (70) 20 (68.9) 0.931
Female 18 (30.5) 9 (30) 9 (31)
HTN n (%) 13 (22) 7 (23.3) 6 (20.6) 0.807
DM n (%) 16 (27.1) 6 (20) 10 (34.4) 0.211
Chronic lung disease n (%) 2 (3.3) 2 (6.6) 0 (0) 0.157
HR/min 95 (89,105) 92.5 (89,100) 96 (90,108) 0.280
Systolic BP (mmHg) 120 (115,130) 120 (120,130) 120 (110,130) 0.428
Diastolic BP (mmHg) 80 (70,80) 80 (70,80) 80 (70,80) 0.542
RR /min 19 (18,22) 19.5 (18,22) 19 (18,21) 0.927
BT (°C) 37.1 (36.7,37.7) 37.05 (36.5,37.8) 37.1 (36.9,37.6) 0.772
O2 saturation (%) 88 (85,89) 88 (85,89) 88 (85,89) 0.436
WBC (1000/mm3) 5.6 (4.6,8.7) 5.0 (4.2,7) 6.6 (5,10.9) 0.026
Neutrophil (%) 78 (70,83) 74 (70,80) 80 (74,87) 0.114
Lymphocyte (%) 18 (11,22) 19 (14,25) 16 (9,20) 0.085
Hb (g/dl) 13.9 (12.4,15) 13.7 (12.2,15) 14 (13.1,15.1) 0.309
Plt (1000/mm3) 190 (137,226) 186 (133,220) 191 (160,234) 0.457
LDH (U/L) 591 (444,742) 545.5 (473,705) 611 (421,800) 0.677
BUN (mg/dl) 34 (27,58) 30.5 (27,46) 50 (27,68) 0.082
Creatinine (mg/dl) 1.1 (1,1.3) 1 (0.8,1.1) 1.2 (1,1.4) 0.001
K (mEq/L) 4.1 (3.9,4.4) 4 (3.9,4.5) 4.1 (3.9,4.3) 0.813
Na (mEq/L) 138 (136,140) 138 (137,140) 138 (135,143) 0.728
ESR 29 (20,46) 28 (23,50) 31 (20,41) 0.808
AST (U/L) 31 (21,42) 34.5 (21,53) 29 (18,40) 0.271
ALT (U/L) 35 (27,45) 34 (27,42) 38 (24,47) 0.596
BS (mg/dl) 120 (106,174) 118 (105,141) 131 (109,229) 0.295
pH 7.3 (7.3,7.4) 7.4 (7.3,7.4) 7.3 (7.3,7.4) 0.210
PaO2 (mmHg) 45 (38,49) 45 (40,49) 45 (37,50) 0.767
PCO2 (mmHg) 39 (36,45) 38 (35,42) 39 (38,47) 0.084
HCO3 (mEq/L) 24 (21,26) 24 (23,26) 24 (21,26) 0.522
Duration of stay in ICU (days) 3 (2,6) 4 (3,6) 3 (2,4) 0.101
Duration of hospitalization (days) 8 (6,11) 9 (7,13) 7 (6,9) 0.014
  1. IVIg Intravenous immunoglobulin, HR Heart rate, BP Blood pressure, RR Respiratory rate, BT Body temperature, WBC White blood cells, HB Hemoglobin, PLT Platelet, LDH Lactate dehydrogenase, BUN Blood urea nitrogen, K Serum potassium, Na Serum sodium, ESR Erythrocyte sedimentation rate, AST Enzymes aspartate transaminase, ALT alanine aminotransferase, ALP Alkaline phosphatase, FBS Fasting blood sugar, BS Blood sugar, PaO2 Partial pressure of oxygen, PCO2 Partial pressure of carbon dioxide, HCO3 Bicarbonate, ICU Intensive care unit
  2. a Data are presented using median (and IQR), except for the following categories (reported as frequency and percentage): sex, HTN, DM, chronic lung disease. $ Comparison between IVIg and control groups