Table 1 Baseline characteristics of E. coli bacteremic patients with bUTI versus non-urinary source
Patients with bUTI (N = 284) | Patients with non-urinary source (N = 178) | p-value | |
|---|---|---|---|
Demographics | |||
Age categories | 0.3666 | ||
< 65 years | 85 (29.9%) | 41 (23.0%) | |
65–74 years | 48 (16.9%) | 34 (19.1%) | |
75–84 years | 80 (28.2%) | 50 (28.1%) | |
> =85 years | 71 (25.0%) | 53 (29.8%) | |
Age median (IQR) | 76.0 (62.0–84.7) | 77.9 (66.7–86.0) | 0.0408 |
Female | 207 (72.9%) | 86 (48.3%) | < 0.0001 |
Long term care home | 44 (15.5%) | 16 (9.0%) | 0.0469 |
Admitting service | 0.0018 | ||
Medicine | 264 (93.0%) | 147 (82.6%) | |
Surgery | 18 (6.3%) | 27 (15.2%) | |
ICU | 2 (0.7%) | 4 (2.3%) | |
Charlson comorbidity score | 0.0875 | ||
0 | 181 (63.7%) | 96 (53.9%) | |
1 | 39 (13.7%) | 27 (15.2%) | |
> =2 | 64 (22.5%) | 55 (30.9%) | |
Charlson comorbidity | |||
Stroke | 21 (7.4%) | 8 (4.5%) | 0.2416 |
Dementia | 17 (6.0%) | 10 (5.6%) | > 0.9999 |
Diabetes | 22 (7.8%) | 21 (11.8%) | 0.1874 |
Diabetes with complications | 16 (5.6%) | 15 (8.4%) | 0.2562 |
Source of infection | |||
Urinary | 284 (0%) | 0 (0%) | |
Abdomen | 0 (0%) | 109 (61.2%) | |
Biliary | 0 (0%) | 60 (33.7%) | |
Pneumonia | 0 (0%) | 9 (5.1%) | |
History of urinary risk factors | |||
Chronic indwelling Foley catheter | 12 (4.2%) | 4 (2.3%) | 0.3059 |
Benign prostate hypertrophy | 16 (5.6%) | 17 (9.6%) | 0.1373 |
Urinary malignancy | 13 (4.6%) | 6 (3.4%) | 0.6341 |
Prior urinary tract infection | 65 (22.9%) | 15 (8.4%) | < 0.0001 |
Nephrolithiasis | 16 (5.6%) | 14 (7.9%) | 0.3405 |
Cystoscopy | 8 (2.8%) | 0 (0%) | 0.0259 |
Prostate biopsy | 6 (2.1%) | 0 (0%) | 0.0875 |
Other urologic procedure | 37 (13.0%) | 13 (7.3%) | 0.0645 |
Urinary symptoms | |||
Dysuria | 63 (22.2%) | 13 (7.3%) | < 0.0001 |
Urinary urgency | 19 (6.7%) | 5 (2.8%) | 0.0845 |
Urinary frequency | 61 (21.5%) | 5 (2.8%) | < 0.0001 |
Gross hematuria | 14 (4.9%) | 2 (1.1%) | 0.0351 |
Flank pain | 52 (18.3%) | 11 (6.2%) | 0.0001 |
Suprapubic abdominal pain | 43 (15.1%) | 8 (4.5%) | 0.0004 |
Urinary retention | 11 (3.9%) | 5 (2.8%) | 0.6112 |
Urinary signs | |||
Suprapubic tenderness | 20 (7.0%) | 8 (4.5%) | 0.3193 |
CVA tenderness | 28 (9.9%) | 6 (3.4%) | 0.0098 |
Any urinary symptoms or signs | 161 (56.7%) | 41 (23.0%) | < 0.0001 |
Urinalysis | |||
Proteinuria | 203 / 249 (81.5%) | 99 / 139 (71.2%) | 0.0220 |
Hematuria | 221 / 249 (88.8%) | 101 / 139 (72.7%) | 0.0001 |
Leukocytes | 223 / 249 (89.6%) | 73 / 139 (52.5%) | < 0.0001 |
Nitrite | 121 / 249 (48.6%) | 40 / 139 (28.8%) | 0.0002 |
Leukocytes or nitrites | 230 / 249 (92.4%) | 79 / 139 (56.8%) | < 0.0001 |
Severity of Infection | |||
Delirium | 68 (23.9%) | 38 (21.4%) | 0.5703 |
Fever | 209 (73.6%) | 127 (71.4%) | 0.5937 |
Sepsis by SIRS criteria | 274 (96.5%) | 171 (96.1%) | 0.8050 |
Sepsis by qSOFA criteria | 110 (38.7%) | 88 (49.4%) | 0.0264 |
Hypotensive shock SBP < 90 | 223 (78.5%) | 136 (76.4%) | 0.6462 |
Transfer to ICU in 72 h | 19 (6.7%) | 21 (11.8%) | 0.0630 |
Outcome | |||
Death in hospital | 17 (6.0%) | 12 (6.7%) | 0.8442 |