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Table 3 Factors associated with a positive QFT result at visit 1 using different definitions of QFT positivity

From: Interpretation of serial interferon-gamma test results to measure new tuberculosis infection among household contacts in Zambia and South Africa

 

Definition 1

Definition 2a

Definition 3

(≥0.2 IU/ml)

(≥0.35 IU/ml)

(≥0.7 IU/ml)

QFT positive (n)

total (n)

Adjusted

OR (95%CI)b

QFT

positive (n)

total (n)

Adjusted

OR (95%CI)b

QFT positive (n)

total (n)

Adjusted

OR (95%CI)b

Both countries

Total

1361 (68)

1988

 

1243 (63)

1968

 

1103 (57)

1951

 

HIV status

 HIV negative

1026 (72)

1417

1

942 (67)

1402

1

839 (60)

1390

1

 HIV positive, no ARV

288 (58)

496

0.5 (0.4–0.6)

258 (53)

491

0.5 (0.4–0.6)

229 (47)

489

0.5 (0.4–0.6)

 HIV positive & ARV

30 (55)

55

0.4 (0.2–0.8)

28 (51)

55

0.4 (0.3–0.8)

21 (40)

53

0.4 (0.2–0.8)

 Unknown

17 (85)

20

 

15 (75)

20

 

14 (74)

19

 

Zambia

Total

735 (62)

1180

 

669 (57)

1164

 

599 (52)

1150

 

HIV status

 HIV negative

529 (65)

808

1

484 (61)

797

1

435 (55)

788

1

 HIV positive, no ARV

176 (55)

321

0.5 (0.4–0.7)

158 (50)

316

0.5 (0.4–0.7)

142 (45)

314

0.5 (0.4–0.7)

 HIV positive & ARV

18 (49)

37

0.4 (0.2–0.8)

16 (43)

37

0.4 (0.2–0.8)

12 (34)

35

0.3 (0.2–0.7)

 Unknown

12 (86)

14

 

11 (79)

14

 

10 (77)

13

 

Region by TST prevalence

 Lusaka, high TST

249 (68)

369

1

234 (64)

363

1

217 (60)

359

1

 Urban, high TST

207 (63)

331

0.6 (0.4–0.9)

186 (57)

326

0.6 (0.4–0.9)

158 (49)

322

0.6 (0.4–0.9)

 Urban, low TST

205 (57)

357

0.5 (0.4–0.8)

181 (52)

350

0.5 (0.4–0.7)

164 (48)

345

0.5 (0.4–0.7)

 Rural, low TST

74 (58)

127

0.5 (0.3–0.9)

68 (54)

125

0.6 (0.3–0.9)

60 (48)

124

0.6 (0.3–0.9)

South Africa

Total

626 (77)

808

 

574 (71)

804

 

504 (63)

801

 

HIV status

 HIV negative

497 (82)

609

1

458 (76)

605

1

404 (67)

602

1

 HIV positive, no ARV

112 (64)

175

0.4 (0.3–0.6)

100 (57)

175

0.4 (0.3–0.6)

87 (50)

175

0.4 (0.3–0.6)

 HIV positive & ARV

12 (67)

18

0.7 (0.2–2.0)

12 (67)

18

0.7 (0.2–2.0)

9 (50)

18

0.7 (0.2–2.1)

 Unknown

5 (83)

6

 

4 (67)

6

 

4 (67)

6

 

TST prevalence

 High

366 (80)

460

1

338 (74)

457

1

298 (65)

455

1

 Low

260 (75)

348

0.7 (0.5–1.0)

236 (68)

347

0.7 (0.5–1.0)

206 (60)

346

0.7 (0.5–1.0)

  1. aTable A1, additional file, presents unadjusted odds ratios, estimates for sex and age, and p-values
  2. b Adjusted models also included sex, age and HH intervention (yes/no). All variables were simultaneously added to the regression models