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Table 2 Longitudinal association of lung involvement with TBscore and blood hemogram markers in TB and TB-DM patientsa

From: Slow radiological improvement and persistent low-grade inflammation after chemotherapy in tuberculosis patients with type 2 diabetes

 

% lung involvementb

TB (n = 35)

TB-DM (n = 36)

β-coefficient (95% CI)

p-valuec

β-coefficient (95% CI)

p-valuec

TBscore

−0.003(−0.03, 0.02)

0.802

0.02(−0.01, 0.04)

0.143

ESR

0.03(− 0.0003, 0.05)

0.053

0.06 (0.03, 0.09)

< 0.001

Hb

−0.34(− 0.66, − 0.01)

0.041

−1.15(−1.80, − 0.49)

0.001

WBC

0.32 (0.08, 0.56)

0.008

0.41 (0.13, 0.69)

0.004

Lymphocyte

−0.05(− 01.2, 0.02)

0.173

− 0.14(− 0.23, − 0.05)

0.002

Neutrophils

0.06(− 0.003, 0.13)

0.060

0.11 (0.04, 0.18)

0.002

Monocyte

−0.22(− 0.64, 0.20)

0.298

0.01(− 0.40, 0.41)

0.980

Platelet

0.02 (0.01, 0.04)

0.001

0.02 (0.01, 0.03)

0.005

NLR

0.09(−0.02, 0.21)

0.121

0.10(−0.11, 0.31)

0.353

MLR

8.53(−2.43, 19.49)

0.127

6.07(−0.78, 12.93)

0.082

PLR

0.17 (0.07, 0.27)

0.001

0.12 (0.04, 0.20)

0.003

  1. aData were analyzed using Generalized estimating equation (GEE), and the results are expressed as beta β-coefficient and 95% confidence interval (CI). The GEE model was adjusted by age, sex, baseline BMI, SES score, BCG vaccination status and time (to reduce multicollinearity)
  2. bEach of the three zones in the two lungs could have a maximum of 100% pathological involvement, and therefore the total % lung involvement in the upper, middle or lower zones respectively could be maximum 100 + 100 = 200%, while the total % lung involvement including all three zones in both lungs in a patient could be maximum 3 × 100 × 2 = 600%
  3. cp-values demonstrate the significant association of lung involvement and the listed variables in both TB and TB-DM patients
  4. BCG Bacillus Calmette–Guérin, BMI body mass index, CI confidence interval, ESR erythrocyte sedimentation rate, Hb hemoglobin, MLR monocyte-to-lymphocyte ratio, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, SES socioeconomic status, WBC white blood cell