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Table 2 Longitudinal association of lung involvement with TBscore and blood hemogram markers in TB and TB-DM patientsa

From: Slow radiological improvement and persistent low-grade inflammation after chemotherapy in tuberculosis patients with type 2 diabetes

  % lung involvementb
TB (n = 35) TB-DM (n = 36)
β-coefficient (95% CI) p-valuec β-coefficient (95% CI) p-valuec
TBscore −0.003(−0.03, 0.02) 0.802 0.02(−0.01, 0.04) 0.143
ESR 0.03(− 0.0003, 0.05) 0.053 0.06 (0.03, 0.09) < 0.001
Hb −0.34(− 0.66, − 0.01) 0.041 −1.15(−1.80, − 0.49) 0.001
WBC 0.32 (0.08, 0.56) 0.008 0.41 (0.13, 0.69) 0.004
Lymphocyte −0.05(− 01.2, 0.02) 0.173 − 0.14(− 0.23, − 0.05) 0.002
Neutrophils 0.06(− 0.003, 0.13) 0.060 0.11 (0.04, 0.18) 0.002
Monocyte −0.22(− 0.64, 0.20) 0.298 0.01(− 0.40, 0.41) 0.980
Platelet 0.02 (0.01, 0.04) 0.001 0.02 (0.01, 0.03) 0.005
NLR 0.09(−0.02, 0.21) 0.121 0.10(−0.11, 0.31) 0.353
MLR 8.53(−2.43, 19.49) 0.127 6.07(−0.78, 12.93) 0.082
PLR 0.17 (0.07, 0.27) 0.001 0.12 (0.04, 0.20) 0.003
  1. aData were analyzed using Generalized estimating equation (GEE), and the results are expressed as beta β-coefficient and 95% confidence interval (CI). The GEE model was adjusted by age, sex, baseline BMI, SES score, BCG vaccination status and time (to reduce multicollinearity)
  2. bEach of the three zones in the two lungs could have a maximum of 100% pathological involvement, and therefore the total % lung involvement in the upper, middle or lower zones respectively could be maximum 100 + 100 = 200%, while the total % lung involvement including all three zones in both lungs in a patient could be maximum 3 × 100 × 2 = 600%
  3. cp-values demonstrate the significant association of lung involvement and the listed variables in both TB and TB-DM patients
  4. BCG Bacillus Calmette–Guérin, BMI body mass index, CI confidence interval, ESR erythrocyte sedimentation rate, Hb hemoglobin, MLR monocyte-to-lymphocyte ratio, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, SES socioeconomic status, WBC white blood cell