| Disease severity |  | |||
---|---|---|---|---|---|
Laboratory findings | Normal Range | Total (N = 116) | Non-severe (n = 61) | Severe (n = 55) | PValue |
White blood cell count, ×109/L | 3.5–9.5 | 4.9 (3.9–6.1) | 5.0 (3.9–5.7) | 4.9 (3.8–7.2) | 0.3442 |
 >9.5 × 109/L, No./total No. (%) |  | 9/116 (7.8) | 1/61 (1.6) | 8/55 (14.5) | 0.0129 |
 <3.5 × 109/L, No./total No. (%) |  | 17/116 (14.7) | 9/61 (14.8) | 8/55 (14.5) | 1.0000 |
Neutrophil count, ×109/L | 1.8–6.3 | 3.1 (2.2–4.5) | 2.9 (2.1–3.8) | 3.4 (2.5–5.8) | 0.0134 |
Lymphocyte count, ×109/L | 1.1–3.2 | 1.0 (0.7–1.3) | 1.2 (0.9–1.6) | 0.9 (0.6–1.1) | < 0.0001 |
 <1.1 × 109/L, No./total No. (%) |  | 66/116 (56.9) | 24/61 (39.3) | 42/55 (76.4) | < 0.0001 |
Total T cell count,  × 106/L | 955–2860 | 590.5 (361.0–941.8) | 915.0 (481.0–1246.0) | 448 (238.5–644.0) | < 0.0001 |
 <955 × 106/L, No./total No. (%) |  | 65/84 (77.4) | 27/43 (62.8) | 38/41 (92.7) | 0.0014 |
CD4+ T cell count,  × 106/L | 550–1440 | 335.0 (214.8–493.3) | 458.0 (275.0–607.0) | 262.0 (156.5–335.0) | 0.0002 |
 <550 × 106/L, No./total No. (%) |  | 66/84 (78.6) | 29/43 (67.4) | 37/41 (90.2) | 0.0158 |
CD8+ T cell count,  × 106/L | 320–1250 | 217.0 (111.3–359.8) | 285.0 (144.0–435.0) | 157.0 (78.5–297.0) | 0.0052 |
<320 × 106/L, No./total No. (%) |  | 46/84 (54.8) | 13/43 (30.2) | 33/41 (80.5) | < 0.0001 |
Monocyte count, ×109/L | 0.1–0.6 | 0.4 (0.3–0.6) | 0.4 (0.4–0.6) | 0.4 (0.2–0.6) | 0.4886 |
Platelet count, ×109/L | 125–350 | 177.0 (137.0–230.0) | 179.0 (145.0–236.0) | 161.5 (121.8–218.3) | 0.1166 |
Haemoglobinlevel, g/L | 130–175 | 131.0 (118.0–140.0) | 129.0 (120.0–140.5) | 131.0 (115.0–140.0) | 0.7728 |
Prothrombin time, s | 10.0–14.0 | 12.2 (11.5–13.0) | 11.9 (11.5–13.0) | 12.4 (11.6–13.1) | 0.3330 |
Activated partial thromboplastin time, s | 23.5–39.1 | 32.3 (30.1–34.8) | 32.3 (30.2–34.6) | 32.6 (29.8–35.0) | 0.8014 |
D-dimer, ng/mL | 0–243 | 168.0 (92.0–393.5) | 122.0 (75.0–254.0) | 222.0 (132.5–529.0) | 0.0004 |
 >243 ng/mL, No./total No. (%) |  |  | 15/61 (24.6) | 25/55 (45.5) | 0.0204 |
Creatinine, umol/L | 45–110 | 69.5 (56.0–81.0) | 68.5 (54.3–75.8) | 72.0(58.8–86.5) | 0.0156 |
 >110umol/L, No./total No. (%) |  | 8/116 (6.9) | 0/61 (0) | 8/55 (14.5) | 0.0019 |
Blood urea nitrogen, mmol/L | 2.5–6.3 | 4.4 (3.4–5.8) | 3.9 (3.2–5.0) | 4.9 (3.5–7.0) | 0.0080 |
 >6.3 mmol/L, No./total No. (%) |  | 22/116 (19.0) | 5/61 (8.2) | 17/55 (30.9) | 0.0021 |
Alanine aminotransferase, U/L | 9–50 | 24.0 (17.3–37.8) | 22.0 (15.5–37.5) | 27.0 (20.0–39.0) | 0.1227 |
 >50.0 U/L, No./total No. (%) |  | 23/116 (19.8) | 11/61 (18.0) | 12/55 (21.8) | 0.6470 |
Aspartate aminotransferase, U/L | 15–40 | 34.5 (25.0–52.8) | 31.0 (22.5–49.5) | 38.0 (26.0–59.0) | 0.0810 |
 >40.0 U/L, No./total No. (%) |  | 46/116 (39.7) | 21/61 (34.2) | 25/55 (45.5) | 0.2573 |
Total bilirubin, umol/L | 4.42–20.52 | 11.0 (8.1–14.1) | 11.0 (8.3–13.0) | 10.5 (7.8–16.3) | 0.9308 |
Creatinekinase–MB, U/L | 0–24 | 17.0 (15.0–21.0) | 17.0 (15.0–22.5) | 18.0 (15.8–20.0) | 0.6960 |
 >24.0 U/L, No./total No. (%) |  | 19/116 (16.4) | 12/61 (19.7) | 7/55 (12.7) | 0.4518 |
Lactate dehydrogenase, U/L | 109–225 | 245.5 (194.3–319.8) | 225.0 (184.0–303.5) | 275.0 (212.0–378.0) | 0.0041 |
 >225.0 U/L, No./total No. (%) |  | 69/116 (59.5) | 30/61 (49.2) | 39/55 (70.9) | 0.0230 |
Hypersensitive troponin T, ng/mL | <0.02 | 0.008 (0.005–0.013) | 0.007 (0.004–0.01) | 0.0115 (0.006–0.0175) | 0.0015 |
 >0.02 ng/mL, No./total No. (%) |  | 16/116 (13.8) | 4/61 (6.6) | 12/55 (21.8) | 0.0288 |
Myoglobin, ng/mL | 28–72 | 39.4 (22.3–92.7) | 26.1 (21.0–47.8) | 54.1 (33.4–120.7) | 0.0002 |
 >72.0 ng/mL, No./total No. (%) |  | 34/116 (29.3) | 12/61 (19.7) | 22/55 (40.0) | 0.0096 |
NT-proBNP, pg/mL |  | 71.5 (27.0–363.5) | 37.0 (19.0–118.8) | 233.0 (53.3–693.0) | < 0.0001 |
elevated cases, No./total No. (%) | Â | 8/116 (6.9) | 1/61 (1.6) | 7/55 (12.8) | 0.0260 |
Procalcitonin, ng/mL | 0.00–0.50 | 0.07 (0.03–0.16) | 0.05 (0.03–0.09) | 0.09 (0.06–0.23) | < 0.0001 |
 ≥ 0.5 ng/mL, No./total No. (%) |  | 8/116 (6.9) | 2/61 (3.3) | 6/55 (10.9) | 0.1473 |
IL-6, pg/mL | 0–7.0 | 18.7 (7.7–46.4) | 11.8 (3.3–27.5) | 33.0 (13.1–69.2) | < 0.0001 |
C-reactive protein level, mg/L | 0–10 | 15.1 (9.0–50.9) | 10.0 (7.0–27.5) | 40.0 (10.0–8.0) | 0.0023 |
Sodium, mmol/L | 137.0–147.0 | 138.8 (137.1–141.0) | 140.0 (138.2–141.7) | 138.0 (134.8–139.3) | 0.0001 |
Potassium, mmol/L | 3.5–5.3 | 4.0 (3.5–4.3) | 3.9 (3.5–4.3) | 4.1 (3.6–4.3) | 0.4548 |
 >5.3 mmol/L, No./total No. (%) |  | 1/116 (0.9) | 0/61 (0) | 1/55 (1.8) | 0.4741 |
 <3.5 mmol/L, No./total No. (%) |  | 24/116 (20.7) | 12/61 (19.7) | 12/55 (21.8) | 0.8213 |
Chloride, mmol/L | 99.0–110.0 | 103.3 (99.8–105.5) | 104.1 (101.3–106.2) | 102.2 (99.2–103.8) | 0.0011 |
Calcium, mmol/L | 2.02–2.6 | 2.10 (2.04–2.21) | 2.14 (2.09–2.28) | 2.07 (2.02–2.13) | < 0.0001 |
Magnesium, mmol/L | 0.6–1.2 | 0.73 (0.68–0.78) | 0.76 (0.70–0.79) | 0.70 (0.64–0.76) | 0.0025 |