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Table 3 Laboratory Findings of Patients Infected With COVID-19 on Admission to Hospital

From: Clinical characteristics of 116 hospitalized patients with COVID-19 in Wuhan, China: a single-centered, retrospective, observational study

  Disease severity  
Laboratory findings Normal Range Total (N = 116) Non-severe (n = 61) Severe (n = 55) PValue
White blood cell count, ×109/L 3.5–9.5 4.9 (3.9–6.1) 5.0 (3.9–5.7) 4.9 (3.8–7.2) 0.3442
 >9.5 × 109/L, No./total No. (%)   9/116 (7.8) 1/61 (1.6) 8/55 (14.5) 0.0129
 <3.5 × 109/L, No./total No. (%)   17/116 (14.7) 9/61 (14.8) 8/55 (14.5) 1.0000
Neutrophil count, ×109/L 1.8–6.3 3.1 (2.2–4.5) 2.9 (2.1–3.8) 3.4 (2.5–5.8) 0.0134
Lymphocyte count, ×109/L 1.1–3.2 1.0 (0.7–1.3) 1.2 (0.9–1.6) 0.9 (0.6–1.1) < 0.0001
 <1.1 × 109/L, No./total No. (%)   66/116 (56.9) 24/61 (39.3) 42/55 (76.4) < 0.0001
Total T cell count,  × 106/L 955–2860 590.5 (361.0–941.8) 915.0 (481.0–1246.0) 448 (238.5–644.0) < 0.0001
 <955 × 106/L, No./total No. (%)   65/84 (77.4) 27/43 (62.8) 38/41 (92.7) 0.0014
CD4+ T cell count,  × 106/L 550–1440 335.0 (214.8–493.3) 458.0 (275.0–607.0) 262.0 (156.5–335.0) 0.0002
 <550 × 106/L, No./total No. (%)   66/84 (78.6) 29/43 (67.4) 37/41 (90.2) 0.0158
CD8+ T cell count,  × 106/L 320–1250 217.0 (111.3–359.8) 285.0 (144.0–435.0) 157.0 (78.5–297.0) 0.0052
<320 × 106/L, No./total No. (%)   46/84 (54.8) 13/43 (30.2) 33/41 (80.5) < 0.0001
Monocyte count, ×109/L 0.1–0.6 0.4 (0.3–0.6) 0.4 (0.4–0.6) 0.4 (0.2–0.6) 0.4886
Platelet count, ×109/L 125–350 177.0 (137.0–230.0) 179.0 (145.0–236.0) 161.5 (121.8–218.3) 0.1166
Haemoglobinlevel, g/L 130–175 131.0 (118.0–140.0) 129.0 (120.0–140.5) 131.0 (115.0–140.0) 0.7728
Prothrombin time, s 10.0–14.0 12.2 (11.5–13.0) 11.9 (11.5–13.0) 12.4 (11.6–13.1) 0.3330
Activated partial thromboplastin time, s 23.5–39.1 32.3 (30.1–34.8) 32.3 (30.2–34.6) 32.6 (29.8–35.0) 0.8014
D-dimer, ng/mL 0–243 168.0 (92.0–393.5) 122.0 (75.0–254.0) 222.0 (132.5–529.0) 0.0004
 >243 ng/mL, No./total No. (%)    15/61 (24.6) 25/55 (45.5) 0.0204
Creatinine, umol/L 45–110 69.5 (56.0–81.0) 68.5 (54.3–75.8) 72.0(58.8–86.5) 0.0156
 >110umol/L, No./total No. (%)   8/116 (6.9) 0/61 (0) 8/55 (14.5) 0.0019
Blood urea nitrogen, mmol/L 2.5–6.3 4.4 (3.4–5.8) 3.9 (3.2–5.0) 4.9 (3.5–7.0) 0.0080
 >6.3 mmol/L, No./total No. (%)   22/116 (19.0) 5/61 (8.2) 17/55 (30.9) 0.0021
Alanine aminotransferase, U/L 9–50 24.0 (17.3–37.8) 22.0 (15.5–37.5) 27.0 (20.0–39.0) 0.1227
 >50.0 U/L, No./total No. (%)   23/116 (19.8) 11/61 (18.0) 12/55 (21.8) 0.6470
Aspartate aminotransferase, U/L 15–40 34.5 (25.0–52.8) 31.0 (22.5–49.5) 38.0 (26.0–59.0) 0.0810
 >40.0 U/L, No./total No. (%)   46/116 (39.7) 21/61 (34.2) 25/55 (45.5) 0.2573
Total bilirubin, umol/L 4.42–20.52 11.0 (8.1–14.1) 11.0 (8.3–13.0) 10.5 (7.8–16.3) 0.9308
Creatinekinase–MB, U/L 0–24 17.0 (15.0–21.0) 17.0 (15.0–22.5) 18.0 (15.8–20.0) 0.6960
 >24.0 U/L, No./total No. (%)   19/116 (16.4) 12/61 (19.7) 7/55 (12.7) 0.4518
Lactate dehydrogenase, U/L 109–225 245.5 (194.3–319.8) 225.0 (184.0–303.5) 275.0 (212.0–378.0) 0.0041
 >225.0 U/L, No./total No. (%)   69/116 (59.5) 30/61 (49.2) 39/55 (70.9) 0.0230
Hypersensitive troponin T, ng/mL <0.02 0.008 (0.005–0.013) 0.007 (0.004–0.01) 0.0115 (0.006–0.0175) 0.0015
 >0.02 ng/mL, No./total No. (%)   16/116 (13.8) 4/61 (6.6) 12/55 (21.8) 0.0288
Myoglobin, ng/mL 28–72 39.4 (22.3–92.7) 26.1 (21.0–47.8) 54.1 (33.4–120.7) 0.0002
 >72.0 ng/mL, No./total No. (%)   34/116 (29.3) 12/61 (19.7) 22/55 (40.0) 0.0096
NT-proBNP, pg/mL   71.5 (27.0–363.5) 37.0 (19.0–118.8) 233.0 (53.3–693.0) < 0.0001
elevated cases, No./total No. (%)   8/116 (6.9) 1/61 (1.6) 7/55 (12.8) 0.0260
Procalcitonin, ng/mL 0.00–0.50 0.07 (0.03–0.16) 0.05 (0.03–0.09) 0.09 (0.06–0.23) < 0.0001
 ≥ 0.5 ng/mL, No./total No. (%)   8/116 (6.9) 2/61 (3.3) 6/55 (10.9) 0.1473
IL-6, pg/mL 0–7.0 18.7 (7.7–46.4) 11.8 (3.3–27.5) 33.0 (13.1–69.2) < 0.0001
C-reactive protein level, mg/L 0–10 15.1 (9.0–50.9) 10.0 (7.0–27.5) 40.0 (10.0–8.0) 0.0023
Sodium, mmol/L 137.0–147.0 138.8 (137.1–141.0) 140.0 (138.2–141.7) 138.0 (134.8–139.3) 0.0001
Potassium, mmol/L 3.5–5.3 4.0 (3.5–4.3) 3.9 (3.5–4.3) 4.1 (3.6–4.3) 0.4548
 >5.3 mmol/L, No./total No. (%)   1/116 (0.9) 0/61 (0) 1/55 (1.8) 0.4741
 <3.5 mmol/L, No./total No. (%)   24/116 (20.7) 12/61 (19.7) 12/55 (21.8) 0.8213
Chloride, mmol/L 99.0–110.0 103.3 (99.8–105.5) 104.1 (101.3–106.2) 102.2 (99.2–103.8) 0.0011
Calcium, mmol/L 2.02–2.6 2.10 (2.04–2.21) 2.14 (2.09–2.28) 2.07 (2.02–2.13) < 0.0001
Magnesium, mmol/L 0.6–1.2 0.73 (0.68–0.78) 0.76 (0.70–0.79) 0.70 (0.64–0.76) 0.0025