Table 5 Performance characteristics of the three tests in Bafia HD. Summary of sensitivity, specificity, PPV and NPV for microscopy, actin-qPCR and O-150 LAMP at different time points following direct observed treatment of microfilaridermic individuals with ivermectin in Bafia health district

89.6 (61.6–99.9)

99.3 (93.0–100)

97.6 (76.9–100)

96.9 (86.2–100)

89.6 (64.5–99.6)

96.8 (87.5–99.9)

89.6 (62.2–99.7)

96.8 (87.2–99.9)

97.6 (78.7–100)

92.1 (80.6–98.8)

79.0 (53.2–97.1)

99.2 (91.9–100)

71.4 (45.8–91.8)

96.9 (88.0–99.8)

90.6 (67.0–99.5)

88.8 (74.8–97.3)

97.5 (75.8–100)

97.0 (86.3–100)

93.2 (69.3–99.9)

98.9 (87.8–100)

97.5 (79.0–100)

88.7 (75.0–97.6)

78.6 (54.5–95.7)

98.8 (89.1–100)

80.6 (62.9–93.1)

94.8 (81.3–99.6)

94.9 (80.6–99.6)

80.8 (61.5–93.4)

98.9 (87.3–100)

98.5 (84.6–100)

98.8 (86.4–100)

98.7 (83.4–100)

99.0 (90.1–100)

76.6 (56.3–91.6)

83.4 (66.9–94.3)

98.6 (85.2–100)

80.7 (68.4–90.2)

97.4 (93.1–99.5)

94.5 (85.1–98.9)

90.3 (83.1–95.2)

98.1 (90.0–100)

97.6 (92.7–99.8)

95.7 (87.1–99.6)

99.0 (94.2–100)

99.4 (93.4–100)

87.1 (79.4–93.1)

80.7 (69.6–89.9)

99.6 (95.8–100)