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Table 5 Predictors of 14-day mortality in children with Pseudomonas aeruginosa bloodstream infection

From: Pseudomonas aeruginosa bloodstream infection at a tertiary referral hospital for children

Variable

Unadjusted OR (95% confidence interval)

P-value

Adjusted OR (95% confidence interval)

P value

Age category N = 91

  < 1 year

1

 

_

 

  ≥ 1 year

0.66 (0.23–1.93)

0.45

  

Weight N = 88

Normal weight

1

   

Moderate or severe underweight

0.44 (0.15–1.32)

0.10

1.60 (0.330–7.803)

0.557

Admission in a health care facility 28 days prior to current hospitalisation

0.80 (0.27–2.4)

0.79

_

 

Chronic disease (excluding HIV) N = 80

1.2 (0.24–6.13)

0.827

_

 

HIV status

HIV-uninfected

1

   

HIV-infected

1.34 (0.32–5.68)

0.70

_

 

HIV status unknown

0.89 (0.22–3.62)

0.87

  

Nature of infection

IPOA

1

   

HAI

0.202 (0.066–0.619)

0.005

0.083 (0.01–0.60)

0.013

MDR, XDR or PDR isolates

1.05 (0.30–3.61)

0.945

_

 

Appropriate empiric antibiotic

0.19 (0.06–0.63)

0.007

0.23 (0.07–0.82)

0.023

Presence of a central venous assess device

1.5(0.46–5.06)

0.495

 

Burn wounds

2.24 (0.47–10.77)

0.315

_

 

Septic shock

3.29 (1.05–10.23)

0.040

2.27 (0.41–12.55)

0.346

Presence of any organ dysfunction

1.97(0.61–6.44)

0.261

 

Anaemia

1.47 (0.43–4.99)

0.540

 

Surgery during current admission

1.96 (0.64–6.0)

0.235

 

Presence of a central venous access device

1.52(0.46–5.06)

0.495

 

ICU management

Patient in the ICU prior to PABSI diagnosis

0.43 (0.15–1.25)

0.101

0.04 (0.005–0.365)

0.004

Patient requiring ICU care after PABSI diagnosis

1.21 (0.399–3.670)

0.737

 

Number of antipseudomonal antibiotics used as definitive therapy

1 antipseudomonal antibiotic

1

   

2 or more antipseudomonal antibiotics

1.236 (0.345–4.430)

0.745

  
  1. OR Odds ratio, HAI Healthcare-associated infection, IPOA Infection present on admission, MDR Multidrug-resistant, XDR Extensively drug-resistant, PDR Pan drug-resistant