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Table 4 The Consistency comparison between induration and erythema after EC skin test

From: Induration or erythema diameter not less than 5 mm as results of recombinant fusion protein ESAT6-CFP10 skin test for detecting M. tuberculosis infection

 

24 h

48 h

72 h

χ2

P

Erythema ≥5 mm

Erythema<5 mm

Erythema ≥5 mm

Erythema<5 mm

Erythema ≥5 mm

Erythema<5 mm

In TB patients

 Induration ≥5 mm

530

6

623

3

618

2

  

 Induration<5 mm

104

103

52

65

56

64

  

 CR+

83.60%a

 

92.30%

 

91.69%

 

31.99

<0.01

 CR

94.50%

 

95.59%

 

96.97%

 

0.59

0.75

 Consistency

85.20%a

 

92.60%

 

92.16%

 

18.36

<0.01

 Kappa(95%CI)

0.57 (0.50,0.64)

 

0.66(0.58,0.74)

 

0.65(0.57,0.73)

   

In bacteriologically positive TB patients

 Induration ≥5 mm

300

3

340

1

331

1

  

 Induration<5 mm

51

40

29

24

37

25

  

 CR+

85.47%a

 

92.14%

 

89.95%

 

8.62

0.01

 CR

93.02%

 

96.00%

 

96.15%

 

0.43

0.81

 Consistency

86.29%a

 

92.39%

 

90.36%

 

8.19

0.02

 Kappa(95%CI)

0.53 (0.64, 0.42)

 

0.58 (0.71, 0.45)

 

0.52 (0.65, 0.39)

   

In bacteriologically negative TB patients

 Induration ≥5 mm

184

4

226

1

231

0

  

 Induration<5 mm

43

51

18

37

13

35

  

 CR+

81.06%a

 

92.62%

 

94.67%

 

27.02

<0.01

 CR

92.73%

 

97.37%

 

100.00%

 

3.25

0.20

 Consistency

83.33%a

 

93.26%

 

95.34%

 

27.27

<0.01

 Kappa(95%CI)

0.58 (0.68, 0.48)

 

0.76 (0.86, 0.66)

 

0.82 (0.92, 0.72)

   

In extrapulmonary TB patients

 Induration ≥5 mm

45

1

58

0

57

0

  

 Induration<5 mm

11

10

4

5

5

5

  

 CR+

80.36%a

 

93.55%

 

91.94%

 

6.07

0.05

 CR

90.91%

 

100.00%

 

100.00%

 

0.96

0.62

 Consistency

82.09%a

 

94.03

 

92.54%

 

6.06

0.05

 Kappa(95%CI)

0.52 (0.30, 0.74)

 

0.68 (0.40, 0.97)

 

0.63 (0.34, 0.92)

   

In healthy volunteers

 Induration ≥5 mm

35

3

131

3

  

 Induration<5 mm

35

1441

23

1357

  

 CR+

50.00%a

 

85.06%

 

30.84

<0.01

 CR

99.79%

 

99.78%

 

0.01

0.94

 Consistency

97.49%

 

98.28%

 

2.30

0.13

 Kappa(95%CI)

0.64(0.53,0.75)

 

0.90(0.86,0.94)

 

  
  1. CR+ Positive coincidence rate, CR Negative coincidence rate
  2. acompared with 48 h and 72 h or compared with 48 h