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Table 4 The Consistency comparison between induration and erythema after EC skin test

From: Induration or erythema diameter not less than 5 mm as results of recombinant fusion protein ESAT6-CFP10 skin test for detecting M. tuberculosis infection

  24 h 48 h 72 h χ2 P
Erythema ≥5 mm Erythema<5 mm Erythema ≥5 mm Erythema<5 mm Erythema ≥5 mm Erythema<5 mm
In TB patients
 Induration ≥5 mm 530 6 623 3 618 2   
 Induration<5 mm 104 103 52 65 56 64   
 CR+ 83.60%a   92.30%   91.69%   31.99 <0.01
 CR 94.50%   95.59%   96.97%   0.59 0.75
 Consistency 85.20%a   92.60%   92.16%   18.36 <0.01
 Kappa(95%CI) 0.57 (0.50,0.64)   0.66(0.58,0.74)   0.65(0.57,0.73)    
In bacteriologically positive TB patients
 Induration ≥5 mm 300 3 340 1 331 1   
 Induration<5 mm 51 40 29 24 37 25   
 CR+ 85.47%a   92.14%   89.95%   8.62 0.01
 CR 93.02%   96.00%   96.15%   0.43 0.81
 Consistency 86.29%a   92.39%   90.36%   8.19 0.02
 Kappa(95%CI) 0.53 (0.64, 0.42)   0.58 (0.71, 0.45)   0.52 (0.65, 0.39)    
In bacteriologically negative TB patients
 Induration ≥5 mm 184 4 226 1 231 0   
 Induration<5 mm 43 51 18 37 13 35   
 CR+ 81.06%a   92.62%   94.67%   27.02 <0.01
 CR 92.73%   97.37%   100.00%   3.25 0.20
 Consistency 83.33%a   93.26%   95.34%   27.27 <0.01
 Kappa(95%CI) 0.58 (0.68, 0.48)   0.76 (0.86, 0.66)   0.82 (0.92, 0.72)    
In extrapulmonary TB patients
 Induration ≥5 mm 45 1 58 0 57 0   
 Induration<5 mm 11 10 4 5 5 5   
 CR+ 80.36%a   93.55%   91.94%   6.07 0.05
 CR 90.91%   100.00%   100.00%   0.96 0.62
 Consistency 82.09%a   94.03   92.54%   6.06 0.05
 Kappa(95%CI) 0.52 (0.30, 0.74)   0.68 (0.40, 0.97)   0.63 (0.34, 0.92)    
In healthy volunteers
 Induration ≥5 mm 35 3 131 3   
 Induration<5 mm 35 1441 23 1357   
 CR+ 50.00%a   85.06%   30.84 <0.01
 CR 99.79%   99.78%   0.01 0.94
 Consistency 97.49%   98.28%   2.30 0.13
 Kappa(95%CI) 0.64(0.53,0.75)   0.90(0.86,0.94)    
  1. CR+ Positive coincidence rate, CR Negative coincidence rate
  2. acompared with 48 h and 72 h or compared with 48 h
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