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Table 2 Factors associated with the risk of severe laboratory-confirmed COVID-19, Mexico 2020

From: Male gender and kidney illness are associated with an increased risk of severe laboratory-confirmed coronavirus disease

 

Bivariate analysis

 

Multiple analysis

 

RR

95% CI

p

RR

95% CI

p

Sex

 Female

1.00

   

1.00

   

 Male

1.18

1.10

1.25

<  0.001

1.13

1.06

1.20

<  0.001

Age (years)

 15–29

1.00

   

1.00

   

 30–44

1.04

0.96

1.13

0.354

1.02

0.94

1.11

0.585

 45–59

1.37

1.25

1.49

<  0.001

1.26

1.15

1.38

<  0.001

  ≥ 60

1.61

1.45

1.79

<  0.001

1.44

1.29

1.60

<  0.001

Received antyperitc drugs (any)

 No

1.00

   

1.00

   

 Yes

0.96

0.90

1.02

0.198

0.96

0.90

1.01

0.136

Elapsed days from symptoms onset to health-care seeking

  < 1

1.00

   

1.00

   

 1–3

0.91

0.85

0.99

0.039

0.96

0.89

1.02

0.213

 4 or above

1.11

1.02

1.20

<  0.001

1.06

0.99

1.13

0.102

Acute symptoms profile

Fever

 No

1.00

   

1.00

   

 Yes

1.13

1.03

1.25

0.010

1.07

0.98

1.17

0.109

Odynophagia

 No

1.00

   

1.00

   

 Yes

0.91

0.85

0.97

0.005

0.95

0.89

1.01

0.060

Myalgia/arthralgia

 No

1.00

   

1.00

   

 Yes

0.92

0.85

0.99

0.031

0.95

0.88

1.02

0.142

Thoracic pain

 No

1.00

   

1.00

   

 Yes

1.20

1.13

1.28

<  0.001

1.16

1.10

1.24

<  0.001

Personal history of

Tobacco use (ever)

 No

1.00

   

1.00

   

 Yes

1.15

1.04

1.28

0.009

1.06

0.97

1.17

0.210

Obesity (BMI 30 or higher)

 No

1.00

   

1.00

   

 Yes

1.14

1.05

1.23

0.001

1.05

0.98

1.13

0.185

Chronic obstructive pulmonary disease

 No

1.00

   

1.00

   

 Yes

1.49

1.26

1.77

<  0.001

1.12

0.95

1.31

0.183

 

Bivariate analysis

 

Multiple analysis

 

RR

95% CI

p

RR

95% CI

p

Arterial hypertension

 No

1.00

   

1.00

   

 Yes

1.32

1.22

1.42

<  0.001

1.05

0.97

1.14

0.207

Cardiovascular disease

 No

1.00

   

1.00

   

 Yes

1.39

1.14

1.69

0.001

1.09

0.91

1.31

0.372

Type 2 diabetes mellitus

 No

1.00

   

1.00

   

 Yes

1.34

1.23

1.47

<  0.001

1.06

0.96

1.16

0.239

Chronic kidney disease

 No

1.00

   

1.00

   

 Yes

1.65

1.29

2.10

<  0.001

1.31

1.04

1.64

0.020

Immunosuppression

 No

1.00

   

1.00

   

 Yes

1.33

1.08

1.64

0.008

1.14

0.94

1.37

0.180

  1. Abbreviations: COVID-19 Coronavirus disease 2019, RR Risk Ratios estimated through linear regression models, BMI Body mass index
  2. Notes: 1) SuperScript™ III Platinum™ One-Step qRT-PCR Kits were used to confirm the CoViD-19; 2) The definition of severe COVID-19 included laboratory conclusive evidence of infection and dyspnea and hospital admission; 3) Risk ratios from multiple analysis were adjusted by the variables listed in the table