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Table 6 Penicillin and tetracycline antimicrobial susceptibility data and identified AMR determinants

From: Plasmid mediated penicillin and tetracycline resistance among Neisseria gonorrhoeae isolates from Kenya

 

Tetracyclines

 

Penicillin G

 

MIC (mg/L)

tetM Plasmid

S10

MIC (mg/L)

β-lactamase

penA allele

PonA

MtrR

PenB

 

Sample ID

DOX

TET

PEN

1

KNY_NGAMR1

0.75

0.064

Absent

V57M

0.064

NP

Pattern XIV

A121G, G120D, −N122

2

KNY_NGAMR2

1.5

0.5

Absent

V57M

64

TEM1a

Pattern II

L421P

G45D, −A13

G120D

3

KNY_NGAMR3

6

16

Present

V57M

48

TEM239

Pattern IX

L421P

A39T

4

KNY_NGAMR4

16

12

Present

V57M

8

TEM1

Pattern XIX

A39T

A121S, N122K

5

KNY_NGAMR5

12

16

Present

V57M

3

TEM1

Pattern IX

L421P

H105Y

A121G, G120N, −N122

6

KNY_NGAMR6

0.75

0.75

Absent

V57M

0.094

NP

Pattern II

A39T

7

KNY_NGAMR7

12

16

Present

V57M

> 256

TEM239

Pattern XXII

L421P

A121S, N122K

8

KNY_NGAMR8

0.5

0.5

Absent

V57M

0.064

NP

Pattern XIV

L421P

A39T

A121G, G120D, −N122

9

KNY_NGAMR10

24

32

Present

V57M

> 256

TEM1

Pattern II

A39T

10

KNY_NGAMR11

12

12

Present

V57M

12

TEM1

Pattern XIV

L421P

A39T

A121G, G120D, −N122

11

KNY_NGAMR13

12

12

Present

V57M

8

TEM1

Pattern XIV

L421P

A39T

A121G, G120D, −N122

12

KNY_NGAMR14

8

24

Present

V57M

64

TEM1

Pattern II

A39T

A121S, N122K

13

KNY_NGAMR15

16

32

Present

V57M

48

TEM1

Pattern XIV

L421P

A39T

A121G, −N122

14

KNY_NGAMR16

8

4

Present

V57M

0.19

NP

Pattern XIV

A39T

A121G, −N122

15

KNY_NGAMR17

12

16

Present

V57M

0.38

NP

Pattern XXII

L421P

T86A, D79N, H105Y

16

KNY_NGAMR18

32

24

Present

V57M

0.5

TEM1

Pattern XIX

A39T

17

KNY_NGAMR19

96

64

Presentb

V57M

0.19

NP

Pattern XIV

L421P

A39T

18

KNY_NGAMR20

16

24

Present

V57M

12

TEM1

Pattern IX

L421P

A39T

A121G, G120D, −N122

19

KNY_NGAMR21

16

24

Present

V57M

32

TEM1

Pattern XIV

L421P

A39T

A121G, G120D, −N122

20

KNY_NGAMR22

12

32

Present

V57M

2

TEM1

Pattern XIX

A39T

21

KNY_NGAMR23

16

8

Present

V57M

12

TEM1

Pattern IX

L421P

A39T

A121G, G120D, −N122

22

KNY_NGAMR24

16

16

Present

V57M

2

TEM1

Pattern XIX

A39T

23

KNY_NGAMR26

24

32

Present

V57M

8

TEM239

Pattern XIV

A39T

A121G, −N122

24

KNY_NGAMR27

16

32

Present

V57M

1

TEM239

Pattern XIV

A39T

25

KNY_NGAMR28

24

32

Present

V57M

96

TEM1

Pattern II

A39T

A121G, −N122

26

KNY_NGAMR29

4

12

Present

V57M

0.094

NP

Pattern XIV

L421P

A39T

A121G, −N122

27

KNY_NGAMR30

12

12

Present

V57M

12

TEM1

pattern XIV

L421P

A39T

A121G, −N122

28

KNY_NGAMR31

24

48

Present

V57M

0.38

NP

Pattern II

A39T

A121G, G120D, −N122

29

KNY_NGAMR32

1

0.5

Absent

V57M

8

TEM1

Pattern XIV

L421P

A39T

A121G, G120D, −N122

30

KNY_NGAMR33

24

32

Present

V57M

3

NP

Pattern XIV

A39T

A121G, −N122

31

KNY_NGAMR35

24

48

Present

V57M

> 256

TEM1

Pattern II

A39T

32

KNY_NGAMR41

12

12

Present

V57M

32

TEM1

Pattern XIX

A39T

33

KNY_NGAMR42

12

24

Present

V57M

32

TEM1

Pattern XIV

T86A, D79N, H105Y

34

KNY_NGAMR50

32

16

Present

V57M

16

TEM1

Pattern II

A39T

A121G, G120D, −N122

35

KNY_NGAMR53

16

6

Present

V57M

6

TEM239

Pattern XIV

L421P

A39T

A121G, −N122

36

KNY_NGAMR54

8

2

Present

V57M

6

NP

Pattern XXII

A39T

  1. DOX Doxycycline, TET Tetracycline, PEN Penicillin (a)β-lactamase encoding plasmid with an Asian plasmid backbone, (b)Dutch TetM determinant, NP Not present, “-” no mutation identified, (−N122)- deletion of N at position 122 of PenB, (−A13)- Adenine deletion in the 13 bp inverted repeat region between the − 10 and − 35 hexamers of the mtrR promoter
  2. Pattern XXII; D346, F505L, A511V, A517G H542N, P553V, K556Q, I557V, I567V, N575, A576V
  3. Pattern IX; D346, F505L, A511V, A517G, P552L
  4. Pattern XIX; D346, F505L, A511V, A517G, H542N, I567V, N575, A576V
  5. Pattern XIV; D346, F505L, A511V, A517G, H542N
  6. Pattern II; D346, F505L, A511V, A517G