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Table 7 Association of different factors with clustering of M. tuberculosis complex

From: Molecular epidemiology of clinical Mycobacterium tuberculosis complex isolates in South Omo, Southern Ethiopia

Characteristics Total N (%) Clustered N (%) COR (95% CI) P value AOR (95% CI) P value
Sex
 Female 64 (41.0) 46 (71.9) 1.00   NA  
 Male 92 (59.0) 68 (73.9) 1.11 (0.54–2.27) 0.778   
Age in years
 15–29 70 (44.9) 55 (78.6) 1.00   NA  
 30–44 59 (37.8) 41 (69.5) 0.62 (0.28–1.38) 0.241   
  > =45 27 (17.3) 18 (66.7) 0.55 (0.20–1.46) 0.227   
TB Type
 PTB 130 (83.3) 92 (70.8) 1.00   NA  
 EPTB 26 (16.7) 22 (84.6) 2.27 (0.73–7.04) 0.155   
Medical history
 New cases 148 (94.9) 107 (72.3) 1.00   NA  
 Retreat. Cases 8 (5.1) 7 (87.5) 2.68 (0.32–22.48) 0.363   
Residential area
 Non-pastoral 70 (51.1) 48 (68.6) 1.00   1  
 Pastoral 67 (48.9) 56 (83.6) 2.33 (1.03–5.30) 0.043 2.29 (0.82–6.35) 0.112
Major lineagesa
 EAI 35 (22.9) 30 (85.7) 1.00   1.00  
 EA 105 (68.6) 78 (74.3) 0.48 (0.17–1.37) 0.170 0.59 (0.16–2.22) 0.439
 IO 10 (6.5) 4 (40.0) 0.11 (0.02–0.54) < 0.006 0.24 (0.03–1.83) 0.169
 Lineage_7 3 (2.0) 2 (66.7) 0.33 (0.03–4.40) 0.404 0.22 (0.01–3.50) 0.110
SIT status
 Shared type 119 (76.3) 101 (84.9) 1.00   1.00  
 Orphan 37 (23.7) 13 (35.1) 0.10 (0.04–0.22) < 0.001 0.09 (0.04–0.25) < 0.001
Lineagea
 Delhi/CAS 37 (26.6) 30 (81.1) 1.00   NA  
 Haarlem 22 (15.8) 16 (72.7) 0.62 (0.18–2.17) 0.456   
 URAL 22 (15.8) 15 (68.2) 0.50 (0.15–1.69) 0.264   
 Ethiopia_2 32 (23.0) 28 (87.5) 1.63 (0.43–6.19) 0.470   
 TUR 10 (7.2) 7 (70.0) 0.54 (0.11–2.65) 0.452   
 Ethiopia_3 13 (9.4) 11 (84.6) 1.28 (0.23–7.14) 0.776   
 Ethiopia_1 3 (2.2) 2 (66.7) 0.47 (0.04–5.90) 0.556   
  1. aSub-categories having only singletons or clustered (based on strain clustering data using spoligotype patterns) were excluded from the regression analysis; NA: Not applicable; some abbreviations sued here were defined in the legend of Table 2