Table 1 Resistance pattern of the MDR-TB strain
Drug | Phenotypical susceptibility testing | Associated mutations |
|---|---|---|
Rifampicin/Rifabutin | Resistant | rpoB gene: mutation S531L |
Isoniazid | Resistant | katG gene: mutation S315T |
Isoniazid/Ethionamide | Resistant | inhA promotor: mutation T-8C |
Ethambutol | Resistant | embB gene: mutation M306I |
Pyrazinamide | Resistant | pncA gene: mutation T47A |
Levofloxacin | Resistant (0,5 mg/l) | gyrA gene: wild type gyrB gene: mutation E540N |
Susceptible (1 mg/l) | ||
Moxifloxacin | Resistant (0,25 mg/l) | |
Susceptible (1 mg/l) | ||
Aminoglycosides | Susceptible | rrs gene: wild type eis gene: wild type |
Cycloserine | Susceptible | |
Para-aminosalicylic acid (PAS) | Susceptible | |
Linezolid | Susceptible | |
Bedaquiline | Susceptible | |
Clofazimine | Susceptible | |
Delamanid | Susceptible |