Table 2 Diagnostic performance of plasma IS6110- and IS1081- dPCR assay for TB

0.79 (0.74–0.85)

40.6 (32.8–42.8) ^a,b

93.4 (86.9–97.3)

6.2 (2.9–12.9)

0.6 (0.6–0.7)

90.0 (80.4–95.9)

51.8 (44.5–59.1)

0.72 (0.66–0.78)

27.1 (20.3–34.8)

93.4 (86.9–97.3)

4.1 (1.9–8.8)

0.8 (0.7–0.9)

85.7 (72.8–94.1)

46.7 (39.8–53.7)

0.67 (0.60–0.73)

42.6 (34.7–50.8)

90.6 (83.3–95.4)

4.5 (2.4–8.4)

0.6 (0.5–0.7)

86.8 (77.1–93.5)

51.9 (44.4–59.3)

0.98 (0.97–1.00)

100.0 (79.4–100.0) ^c,d

93.4 (86.9–97.3)

15.1 (7.4–31.0)

0.0 (−)

69.6 (46.5–87.1)

100.0 (96.3–100.0)

0.95 (0.91–0.99)

68.8 (41.3–89.0) ^e,f

93.4 (86.9–97.3)

10.4 (4.7–22.9)

0.3 (0.2–0.7)

61.1 (35.0–83.2)

95.2 (89.1–98.4)

0.83 (0.77–0.90)

50.0 (36.3–63.7)

93.4 (86.9–97.3)

7.6 (3.5–16.2)

0.5 (0.4–0.7)

80.0 (62.8–91.7)

78.0 (69.7–84.8)

0.81 (0.74–0.88)

39.3 (26.5–53.5)

93.4 (86.9–97.3)

4.2 (2.1–8.2)

0.7 (0.5–0.8)

68.7 (49.7–84.1)

73.8 (65.4–81.2)

0.82 (0.76–0.87)

43.2 (33.9–53.0)

93.4 (86.9–97.3)

6.6 (3.1–13.8)

0.6 (0.5–0.7)

87.3 (75.4–94.8)

61.1 (53.1–68.7)

0.75 (0.68–0.81)

33.3 (24.7–42.9)

93.4 (86.9–97.3)

5.1 (2.4–10.8)

0.7 (0.6–0.8)

84.1 (69.7–93.4)

57.2 (49.5–64.7)