|
1
|
Combination therapy of intralesional sodium stibogluconate and other CL therapy modalities such as cryotherapy, systemic antibiotics are superior to monotherapy with sodium stibogluconate.
|
+ 2*
|
−1
|
|
2
|
Combination therapy is superior to monotherapy for any case of CL
|
0*
|
−3
|
|
3
|
Effectiveness of combined intralesional sodium stibogluconate or cryotherapy with liquid nitrogen with antibiotics (e.g., Azithromycin or Doxycycline) is mainly due to overcoming secondary bacterial infection by antibiotics.
|
+ 2*
|
− 3
|
|
4
|
Problems of sodium stibogluconate are interrupted supply to health care providers and lack of original quality sometimes.
|
+ 3*
|
−1
|
|
5
|
Resistance to treatment in CL is due to low efficacy drugs.
|
+ 2*
|
+ 1
|
|
6
|
The use of herbal or homemade remedies by patients, which interfere with treatment, is very common.
|
+ 3*
|
−4
|
|
7
|
Patients noncompliance to the schedule of the treatment plan is the main obstacle for treating patients with CL
|
+ 2*
|
0
|
|
8
|
Fear of patients from treatment modalities and unawareness about the disease makes them not sticking to treatment schedules and instructions.
|
+ 1*
|
−1
|
|
9
|
If Zinc sulfate is given as monotherapy in large doses, it can heal CL patients.
|
−4*
|
−1
|
|
10
|
Rifampicin is a potent and effective anti- CL treatment.
|
−2*
|
0
|
|
11
|
Systematic antifungal drugs (e.g., ketoconazole or fluconazole) are effective in the treatment of CL.
|
−1*
|
0
|
|
12
|
Debridement and dressing of ulcerated lesions of CL have an important role in the treatment plan.
|
−3*
|
−2
|
|
13
|
For CL lesions of up to 4 in number, especially in hidden areas of the body, there is no need for any treatment, and only dressing and tying is enough.
|
−4*
|
−3
|
|
14
|
After decades of serious work and the presence of several options with newer compounds and combinations, there is still a little advance in the treatment of CL, which is not satisfactory for both doctors and patients.
|
−2*
|
+ 2
|
|
15
|
CL course extends more than 1–2 months despite treatment.
|
0*
|
+ 3
|
|
16
|
Resistance to treatment is the main complication of CL treatment.
|
−1*
|
+ 1
|
|
17
|
Cryotherapy with liquid nitrogen is the treatment of choice in children, especially for facial and ear lesions and dry lesions.
|
−1*
|
+ 3
|
|
18
|
The effect of cryotherapy with liquid nitrogen is unpredictable; some patients benefit from cryotherapy sessions while others come back with blistering and ulceration of lesions.
|
+ 1*
|
+ 2
|
|
19
|
Photodynamic therapy for CL lesions is advised for lesions located on cosmetically concerned areas such as the face.
|
−1*
|
+ 1
|
|
20
|
The intralesional sodium stibogluconate method is to inject it until the lesion turns white and is indurated.
|
+ 3*
|
+ 4
|
|
21
|
Systemic sodium stibogluconate is given when there is no response to cryotherapy with liquid nitrogen.
|
−2*
|
−4
|
