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Table 2 Comparison of clinical manifestations, laboratory and radiologic findings in hospitalized elderly CAP patients with clinical failure and clinical success (n = 3011)

From: Disease burden and prognostic factors for clinical failure in elderly community acquired pneumonia patients

Characteristics CF(n = 395) CS(n = 2616) p value
Clinical features
 Fever 208 (52.7) 1364 (52.1) 0.871
 Cough 327 (82.8) 2368 (90.5) <0.001
 Chest pain 20 (5.1) 244 (9.3) 0.004
 Wheezing 214 (54.2) 1034 (39.5) <0.001
 Cyanosis 89 (22.5) 292 (11.2) <0.001
 Lower extremity edema 98 (24.8) 366 (14.0) <0.001
 Mental confusion 2016 (26.8) 137 (5.2) <0.001
 RR > 24beats/min 62 (15.7) 119 (4.5) <0.001
 HR > 125beats/min 34 (8.6) 40 (1.5) <0.001
 Hypotension 92 (23.3) 386 (14.8) <0.001
Laboratory findings
 WBC > 10,000/mm3(n = 2944) 172 (45.1) 762 (29.7) <0.001
 The rate of NE(n = 2917) 0.8 ± 0.2 0.7 ± 0.1 <0.001
 The rate of L(n = 2890) 0.1 ± 0.1 0.2 ± 0.6 0.007
 NE/L(n = 2889) 14.3 ± 16.5 7.1 ± 9.4 <0.001
 HCT<30%(n = 2874) 86 (22.9) 310 (12.4) <0.001
 Cr > 123.76 umol/L (n = 2878) 68 (18.2) 217 (8.7) <0.001
 Glucose> 14 mmol/L(n = 2757) 19 (5.5) 68 (2.8) 0.013
 Na<130 mmol/L(n = 2890) 55 (14.7) 141 (5.6) <0.001
 BUN> 7 mmol/L(n = 2887) 202 (53.6) 689 (27.5) <0.001
 PH<7.3(n = 1884) 24 (7.7) 21 (1.3) <0.001
 PaO2/FiO2<200 mmHg(n = 1857) 70 (23.0) 138 (5.9) <0.001
 Albumin<25 g/L(n = 2863) 57 (15.7) 154 (6.2) <0.001
Complications
 Respiratory failure 329 (83.3) 196 (7.5) <0.001
 Arrhythmia 60 (15.2) 45 (1.7) <0.001
 Acute heart failure 151 (38.2) 199 (7.6) <0.001
 Acute myocardial infarction 24 (6.1) 9 (0.3) <0.001
 Acute liver failure 27 (6.8) 17 (0.6) <0.001
 Acute renal failure 63 (15.9) 14 (0.5) <0.001
 Stroke 17 (4.3) 15 (0.6) <0.001
 DIC 4 (1.0) 1 (0) 0.001
 Gastrointestinal bleeding 47 (11.9) 21 (0.8) <0.001
 Thromboembolic disease 4 (1.0) 13 (0.5) 0.266
Radiology findings on CT
 Multilobe infiltration (n = 3011) 193 (48.9) 1181 (45.1) 0.178
 Pleural effusion (n = 3011) 146 (37.0) 603 (23.1) <0.001
  1. Abbreviations: RR Respiratory rate; HR Heart rate; WBC White blood cell; NE Neutrophil; L Lymphocyte; HCT Hematocrit; Cr Creatinine; Na Sodium; BUN Blood urea nitrogen; PaO2/FiO2, Partial arterial oxygen pressure/fraction of inspired oxygen; DIC Disseminated intravascular coagulation; CT Computed tomography