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Table 1 The distribution of PLWH with virologic failure in ART in the genetic transmission networks

From: Genetic transmission networks of HIV-1 CRF07_BC strain among HIV-1 infections with virologic failure of ART in a minority area of China: a population-based study

 

Genetic transmission network

N = 1050

Unadjusted OR (95% CI)

 

n = 346

%

Socio-demographics

Gender

 Male

240

33.61

714

1.0 (Ref.)

 Female

106

31.55

336

0.91(0.69–1.20)

Age, years

  ≤ 15

34

33.66

101

1.0 (Ref.)

 15 ~ 40

240

32.92

720

0.98(0.63–1.53)

 >40

72

31.44

229

0.90(0.55–1.49)

Occupation

 Employed

12

28.57

42

1.0 (Ref.)

 Peasant

297

33.07

898

1.24(0.62–2.45)

 Students and children

28

35.90

78

1.40(0.62–3.16)

 Unknown

9

28.13

32

–

Current marital status

 Married

263

35.44

742

1.0 (Ref.)

 Single

63

28.38

222

0.72(0.52–1.02)

 Widowed or Divorced

11

21.57

51

0.50(0.25–0.99) **

 Unknown

9

25.71

35

–

Ethnicity

 Han and others

2

25.00

8

1.0 (Ref.)

 Yi

344

33.01

1042

1.48(0.30–7.36)

Education level

 Illiteracy

221

31.80

695

1.0 (Ref.)

 Primary school

116

36.59

317

1.24(0.94–1.64)

 Secondary or above

9

23.68

38

0.67(0.31–1.43)

HIV transmission route

 Heterosexual behaviors

123

32.11

383

1.0 (Ref.)

 Drug injection

139

34.58

402

1.12(0.83–1.50)

 Heterosexual behaviors and drug injection

49

30.63

160

0.93(0.63–1.39)

 Mother to child

35

33.33

105

1.06(0.67–1.67)

CD4+ cell count, cell/μl

  ≤ 200

63

38.65

163

1.0 (Ref.)

 201 ~ 500

174

31.02

561

0.71(0.50–1.03)

 >500

101

33.89

298

0.81(0.55–1.21)

 Unknown

8

28.57

28

–

Viral load, copies/ml

 1000 ~ 10,000

175

33.72

519

1.0 (Ref.)

 10,000 ~ 50,000

101

31.96

316

1.05(0.75–1.48)

 >50,000

70

32.56

215

0.97(0.67–1.41)

Stage of disease

 HIV

143

32.43

441

1.0 (Ref.)

 AIDS

172

33.79

509

1.06(0.81–1.40)

 Unknown

31

31.00

100

–

Time of diagnosis of HIV, years

  < 3

69

36.51

189

1.0 (Ref.)

 3–5

71

36.22

196

0.99(0.65–1.50)

  > 5

206

30.98

665

0.78(0.56–1.10)

HIV related behaviors

Needle sharing

 Had never used illicit drugs or shared a needle

177

31.72

558

1.0 (Ref.)

 Had shared a needle 1 ~ 4 times

91

30.95

294

0.97(0.71–1.31)

 Had shared a needle ≥5 times

78

39.39

198

1.40(1.01–1.96) **

Number of casual sexual partners

 0

199

32.52

612

1.0 (Ref.)

 1 ~ 4

92

34.72

265

1.10(0.81–1.50)

  ≥ 5

55

31.79

173

0.97(0.67–1.39)

History of sexually transmitted diseases except for HIV

 Never

258

31.81

811

1.0 (Ref.)

 Ever

88

36.82

239

1.25(0.92–1.69)

ART related information

Time of ART, years

  ≤ 12

67

40.85

164

1.0 (Ref.)

 12 ~ 36

127

32.90

386

0.71(0.49–1.04)

 >36

100

32.47

308

0.70(0.47–1.04)

 Unknown

52

27.08

192

–

Initial regimen of ART

 TDF + 3TC + EFV/NVP

217

35.11

618

1.0 (Ref.)

 AZT + 3TC + EFV/NVP

63

31.66

199

1.17(0.83–1.64)

 LPV + 3TC + AZT/TDF

13

33.33

39

1.08(0.52–2.24)

 Unknown

53

27.32

194

–

Change of ART regimen

 Never

263

34.07

772

1.0 (Ref.)

 Ever

31

36.05

86

1.09(0.69–1.74)

 Unknown

52

27.08

192

–

Drug resistance (DR)

 No

228

31.58

722

1.0 (Ref.)

 Yes

118

35.98

328

1.22(0.89–1.60)

DR to NNRTI

 No

236

31.85

741

1.0 (Ref.)

 Yes

110

35.60

309

1.18(0.89–1.56)

DR to NRTI

 No

302

32.83

920

1.0 (Ref.)

 Yes

44

33.85

130

1.05(0.71–1.54)

DR to PI

 No

343

33.20

1033

1.0 (Ref.)

 Yes

3

17.65

17

2.32(0.66–8.13)

  1. Unadjusted OR: Unadjusted odds ratios
  2. **P value< 0.01