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Table 1 The distribution of PLWH with virologic failure in ART in the genetic transmission networks

From: Genetic transmission networks of HIV-1 CRF07_BC strain among HIV-1 infections with virologic failure of ART in a minority area of China: a population-based study

  Genetic transmission network N = 1050 Unadjusted OR (95% CI)
  n = 346 %
Socio-demographics
Gender
 Male 240 33.61 714 1.0 (Ref.)
 Female 106 31.55 336 0.91(0.69–1.20)
Age, years
  ≤ 15 34 33.66 101 1.0 (Ref.)
 15 ~ 40 240 32.92 720 0.98(0.63–1.53)
 >40 72 31.44 229 0.90(0.55–1.49)
Occupation
 Employed 12 28.57 42 1.0 (Ref.)
 Peasant 297 33.07 898 1.24(0.62–2.45)
 Students and children 28 35.90 78 1.40(0.62–3.16)
 Unknown 9 28.13 32
Current marital status
 Married 263 35.44 742 1.0 (Ref.)
 Single 63 28.38 222 0.72(0.52–1.02)
 Widowed or Divorced 11 21.57 51 0.50(0.25–0.99) **
 Unknown 9 25.71 35
Ethnicity
 Han and others 2 25.00 8 1.0 (Ref.)
 Yi 344 33.01 1042 1.48(0.30–7.36)
Education level
 Illiteracy 221 31.80 695 1.0 (Ref.)
 Primary school 116 36.59 317 1.24(0.94–1.64)
 Secondary or above 9 23.68 38 0.67(0.31–1.43)
HIV transmission route
 Heterosexual behaviors 123 32.11 383 1.0 (Ref.)
 Drug injection 139 34.58 402 1.12(0.83–1.50)
 Heterosexual behaviors and drug injection 49 30.63 160 0.93(0.63–1.39)
 Mother to child 35 33.33 105 1.06(0.67–1.67)
CD4+ cell count, cell/μl
  ≤ 200 63 38.65 163 1.0 (Ref.)
 201 ~ 500 174 31.02 561 0.71(0.50–1.03)
 >500 101 33.89 298 0.81(0.55–1.21)
 Unknown 8 28.57 28
Viral load, copies/ml
 1000 ~ 10,000 175 33.72 519 1.0 (Ref.)
 10,000 ~ 50,000 101 31.96 316 1.05(0.75–1.48)
 >50,000 70 32.56 215 0.97(0.67–1.41)
Stage of disease
 HIV 143 32.43 441 1.0 (Ref.)
 AIDS 172 33.79 509 1.06(0.81–1.40)
 Unknown 31 31.00 100
Time of diagnosis of HIV, years
  < 3 69 36.51 189 1.0 (Ref.)
 3–5 71 36.22 196 0.99(0.65–1.50)
  > 5 206 30.98 665 0.78(0.56–1.10)
HIV related behaviors
Needle sharing
 Had never used illicit drugs or shared a needle 177 31.72 558 1.0 (Ref.)
 Had shared a needle 1 ~ 4 times 91 30.95 294 0.97(0.71–1.31)
 Had shared a needle ≥5 times 78 39.39 198 1.40(1.01–1.96) **
Number of casual sexual partners
 0 199 32.52 612 1.0 (Ref.)
 1 ~ 4 92 34.72 265 1.10(0.81–1.50)
  ≥ 5 55 31.79 173 0.97(0.67–1.39)
History of sexually transmitted diseases except for HIV
 Never 258 31.81 811 1.0 (Ref.)
 Ever 88 36.82 239 1.25(0.92–1.69)
ART related information
Time of ART, years
  ≤ 12 67 40.85 164 1.0 (Ref.)
 12 ~ 36 127 32.90 386 0.71(0.49–1.04)
 >36 100 32.47 308 0.70(0.47–1.04)
 Unknown 52 27.08 192
Initial regimen of ART
 TDF + 3TC + EFV/NVP 217 35.11 618 1.0 (Ref.)
 AZT + 3TC + EFV/NVP 63 31.66 199 1.17(0.83–1.64)
 LPV + 3TC + AZT/TDF 13 33.33 39 1.08(0.52–2.24)
 Unknown 53 27.32 194
Change of ART regimen
 Never 263 34.07 772 1.0 (Ref.)
 Ever 31 36.05 86 1.09(0.69–1.74)
 Unknown 52 27.08 192
Drug resistance (DR)
 No 228 31.58 722 1.0 (Ref.)
 Yes 118 35.98 328 1.22(0.89–1.60)
DR to NNRTI
 No 236 31.85 741 1.0 (Ref.)
 Yes 110 35.60 309 1.18(0.89–1.56)
DR to NRTI
 No 302 32.83 920 1.0 (Ref.)
 Yes 44 33.85 130 1.05(0.71–1.54)
DR to PI
 No 343 33.20 1033 1.0 (Ref.)
 Yes 3 17.65 17 2.32(0.66–8.13)
  1. Unadjusted OR: Unadjusted odds ratios
  2. **P value< 0.01