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Table 3 The functions of 14 hub genes

From: Gene network in pulmonary tuberculosis based on bioinformatic analysis

Gene Scorea Full name Functionb
CD163 12 Scavenger receptor cysteine-rich type 1 protein M130 Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage.
TLR5 11.02941 Toll-like receptor 5 Participates in the innate immune response to microbial agents.
IFIT1 10.82353 Interferon-induced protein with tetratricopeptide repeats 1 Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5′-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single- stranded RNAs and inhibiting expression of viral messenger RNAs.
IFIT2 10.82353 Interferon-induced protein with tetratricopeptide repeats 2 IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2′-O-methylation of the 5′ cap.
CCR7 10.7451 C-C chemokine receptor type 7 Receptor for the MIP-3-beta chemokine. Belongs to the G-protein coupled receptor 1 family.
CXCR3 11.2 C-X-C chemokine receptor type 3 Isoform 1- Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway.
TLR1 10.7451 Toll-like receptor 1 Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides.
FCGR2A 10.63736 Low affinity immunoglobulin gamma Fc region receptor II-a Binds to the Fc region of immunoglobulins gamma.
CD19 10.7451 B-lymphocyte antigen CD19 Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
IFIH1 10.82353 Interferon-induced helicase C domain-containing protein 1 Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines.
IFI44L 10.82353 Interferon-induced protein 44-like Exhibits a low antiviral activity against hepatitis C virus.
TLR8 10.7451 Toll-like receptor 8 Key component of innate and adaptive immunity.
IFI44 10.82353 Interferon-induced protein 44 This protein aggregates to form microtubular structures.
TLR2 10.7451 Toll-like receptor 2 Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components.
  1. Scorea: indicated MCODE score. Functionb: obtained from NCBI (https://www.ncbi.nlm.nih.gov/)