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Table 3 Concurrent CBC results and CBC-derived ratios for early and late converters at first study visit where IGRA conversion was detected versus time-matched controls

From: The potential of CBC-derived ratios (monocyte-to-lymphocyte, neutrophil-to-lymphocyte, and platelet-to-lymphocyte) to predict or diagnose incident TB infection in Tanzanian adolescents

  Early Converters Negatives at Day 60 Late Converters Negatives at Day 720 p-value p-value p-value
Laboratory Component Mean (S.D.) Mean (S.D.) Mean (S.D.) Mean (S.D.) (EC N60) LC vs N720) (EC vs LC)
White blood cells (WBCs)
 WBC count1 5.62 (1.18) 5.52 (1.44) 5.86 (1.48) 5.43 (1.42) 0.53 0.13 0.48
 Neutrophil count1 2.16 (0.85) 2.27 (1.12) 2.62 (1.24) 2.28 (1.02) 0.92 0.24 0.31
 Neutrophil % 37.5 (11.1) 39.3 (10.7) 43.2 (12.6) 41.2 (12.0) 0.57 0.75 0.24
 Lymphocyte count1 2.69 (0.54) 2.53 (0.63) 2.53 (0.71) 2.41 (0.71) 0.33 0.45 0.40
 Lymphocyte % 48.8 (7.6) 47.0 (9.4) 44.4 (11.5) 45.0 (9.6) 0.50 0.81 0.15
 Monocyte count1 0.405 (0.147) 0.428 (0.204) 0.374 (0.158) 0.448 (0.365) 0.77 0.33 0.42
 Monocyte % 7.2 (2.1) 7.9 (3.9) 6.5 (2.5) 8.4 (7.0) 0.64 0.09 0.30
 Eosinophil count1 0.185 (0.205) 0.177 (0.209) 0.269 (0.281) 0.163 (0.224) 0.84 0.13 0.28
 Eosinophil % 3.3 (3.7) 3.1 (3.3) 4.6 (4.8) 3.0 (3.5) 0.66 0.17 0.29
 Basophil count1 0.181 (0.292) 0.123 (0.116) 0.071 (0.040) 0.143 (0.201) 0.62 0.46 0.42
 Basophil % 3.2 (4.7) 2.4 (2.6) 1.3 (0.9) 2.6 (3.4) 0.55 0.07 0.24
Red blood cells (RBCs)
 RBC count2 4.6 (0.6) 4.7 (0.5) 4.7 (0.5) 4.8 (0.5) 0.53 0.68 0.44
 Hemoglobin (g/dL) 12.1 (1.4) 12.3 (1.0) 13.0 (1.4) 12.7 (1.3) 0.29 0.42 0.04
 Hematocrit (%) 37.7 (4.5) 38.5 (3.3) 40.8 (4.8) 40.1 (4.1) 0.22 0.50 0.05
 MCV (fL) 82.3 (6.1) 82.7 (6.7) 86.0 (4.7) 84.0 (7.0) 0.90 0.27 0.04
 MCH (pg) 26.5 (2.2) 26.6 (2.8) 27.4 (1.8) 26.7 (2.5) 0.98 0.17 0.14
 MCHC (g/dL) 32.2 (1.0) 32.1 (2.1) 31.9 (1.5) 31.8 (1.4) 0.78 0.35 0.68
 RDW (%) 17.1 (2.1) 16.6 (1.5) 16.4 (1.6) 16.8 (2.1) 0.57 0.64 0.38
Platelets
 Platelet count1 276 (81) 311 (168) 272 (95) 289 (79) 0.32 0.37 0.93
CBC-derived Ratios
 MLR 0.15 (0.05) 0.18 (0.10) 0.16 (0.07) 0.20 (0.25) 0.54 0.20 0.88
 NLR 0.82 (0.38) 0.94 (0.57) 1.13 (0.69) 1.01 (0.54) 0.45 0.71 0.15
 PLR 105 (32) 138 (132) 114 (46) 128 (43) 0.11 0.21 0.53
  1. EC early converters, N60 IGRA-negative at day 60 (time-matched controls for early converters), LC late converters, N720 IGRA-negative at day 720 (time-matched controls for late converters), MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, RDW red cell distribution width; 1: units are × 103/mcL; 2: units are × 106/mcL
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