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Table 3 Clinical characteristics and outcomes among the 14 neonates in the 12 pregnancy-associated listeriosis cases

From: Perinatal listeriosis patients treated at a maternity hospital in Beijing, China, from 2013–2018

No. Birth weight (g) Presentation Culture sites Initial antibiotic Switched antibiotic Intubation Complications Outcomes
Feto-neonatal blood CSF Laryngeal swab
1 1610 fetal distress; Apgar 6; SpO2 92% on ambient air; rash (−) / (+) NA NA Yes preterm birth; neonatal asphyxia; pneumonia; hypoglycemia, DIC; septic shock; renal failure; hyperlactacidemia; metabolic acidosis deceased day 2; infant listeriosis
2.1 & 2.2 740/560 fetal distress; decreased fetal movement / / / / / / stillbirth; induced labor death
3 440 fetal distress; decreased fetal movement / / (+) / / / inevitable miscarriage; induced labor infant listeriosis
4 2275 fetal distress; Apgar 9; SOB; SpO2 80% on ambient air; rash (+) (+) (+) NA NA Yes septicemia; preterm birth; CNS infection; meningitis; intrauterine infection; low birth weight; hypoglycemia; DIC; sepsis; thrombocytopenia; myoardial infarction survived; infant listeriosis
5 1000 fetal distress / / / / / / stillbirth death
6 2565 fetal distress; Apgar 10; SpO2 95% on ambient air (+) / (+) cefotoxime + PNG 5d meropenem + PNG 9d No septicemia; preterm birth; intrauterine infection survived; infant listeriosis
7 3565 fetal distress; Apgar 8; SpO2 88% on ambient air; meconium aspiration (+) / (+) piperacillin 3d ceftazidime + vancomycin 12d Yes septicemia; intrauterine infection; pneumonia; hyperlactacidemia; neonatal encephalopathy; anemia; myoardial infarction; thrombocytopenia survived; infant listeriosis
8 380 intrauterine fetal death / / / / / / inevitable miscarriage induced labor
9.1 2730 fetal distress; Apgar 8; SOB; SpO2 92% on ambient air (−) (−) (−) cefepime + PNG 10d No No preterm birth; pneumonia; patent foramen ovale survived
9.2 2285 fetal distress; Apgar 7; SOB; SpO2 90% on ambient air (+) (+) (+) meropenem + PNG 19d No No preterm birth; septicemia; low birth weight; CNS infection; meningitis; liver function lesion, pneumonia; metabolic acidosis; hypoglycemia; anemia, neutropenia; patent foramen ovale; patent ductus arteriosus survived; infant listeriosis
10 620 fetal distress / / / / / / stillbirth death
11 2810 fetal distress; Apgar 10; SpO2 96% on ambient air; cyanosis (−) / (−) PNG + latamoxef 7d cefepime 7d No preterm birth; pneumonia; neonatal infection; hypocalcemia; neonatal jaundice; patent foramen ovale; hydronephrosis survived
12 820 fetal distress; Apgar 8; SpO2 94% on ambient air / / (−) / / Yes extremely low birth weight; preterm birth; hyperlactacidemia; NRDS deceased day 1
  1. Abbreviations: NA not available, C-section cesarean section, SpO2 oxygen saturation from pulse oximetry, SOB shortness of breath, DIC disseminated intravascular coagulation, NRDS neonatal respiratory distress syndrome, CSF cerebrospinal fluid, PNG penicillin