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Table 1 The baseline characteristics of patients in the deceased and survival groups

From: The impact of early neuraminidase inhibitor therapy on clinical outcomes in patients hospitalised with influenza A-related pneumonia: a multicenter, retrospective study

Variables Total (n = 693) Deceased group (n = 136) Survival group (n = 557) p-value
Male (n,) 461 (66.5) 92 (67.6) 369 (66.2) 0.757
Age (median, IQR, years) 61.0 (36.0–73.0) 61.5 (28.0–76.0) 59.0 (36.0–72.0) 0.963
BMI ≥ 30 kg/m2 (n, %)a 48 (6.9) 0 (0.0) 48 (8.6) < 0.001
Comorbidities (n, %)
 Hypertension 252 (36.4) 48 (35.3) 204 (36.6) 0.772
 Cardiovascular diseasea 136 (19.6) 48 (35.3) 88 (15.8) < 0.001
 Diabetes mellitus 92 (13.3) 14 (10.3) 78 (14.0) 0.253
 Cerebrovascular disease 72 (10.4) 10 (7.4) 62 (11.1) 0.195
 COPDa 40 (5.8) 3 (2.2) 37 (6.6) 0.047
 Asthma 19 (2.7) 2 (1.5) 17 (3.1) 0.222
 Chronic kidney disease 16 (2.3) 6 (4.4) 10 (1.8) 0.133
 Malignant solid tumor 16 (2.3) 0 (0.0) 16 (2.9) 0.193
 Smoking historya 243 (35.1) 68 (50.0) 175 (31.4) < 0.001
Clinical and radiologic characteristics (n, %)
 Respiratory rates ≥30 times/min 121 (17.5) 25 (18.4) 96 (17.2) 0.752
 Confusiona 32 (4.6) 32 (23.5) 0 (0.0) < 0.001
 SBP < 90 mmHg 8 (1.2) 0 (0.0) 8 (1.4) 0.338
 Leukocytes > 10 × 109/L a 118 (17.0) 42 (30.9) 76 (13.6) < 0.001
 Lymphocytes < 0.8 × 109/L a 299/677 (44.2) 120 (88.2) 179/541 (33.1) < 0.001
 Hb < 100 g/La 69 (10.0) 34 (25.0) 35 (6.3) < 0.001
 ALB < 35 g/L 58/639 (9.1) 12/131 (9.2) 46/508 (9.1) 0.970
 BUN > 7 mmol/La 183/685 (26.7) 97 (71.3) 86/549 (15.7) < 0.001
 BG > 11 mmol/L 48 (6.9) 8 (5.9) 40 (7.2) 0.397
 Arterial pH < 7.35a 120/639 (18.8) 60/136 (44.1) 60/503 (11.9) < 0.001
 pO2/FiO2 ≤ 250 mmHg a 172/639 (26.9) 28/136 (20.6) 144/503 (28.6) 0.061
 Pleural effusiona 120 (17.3) 36 (26.5) 84 (15.1) < 0.001
Early NAI usea (n, %)a 232 (33.5) 60 (43.4) 172 (30.9) 0.003
Duration from illness onset to NAI use (days, median, IQR)a 3.0 (1.0–4.0) 2.5 (1.0–3.0) 3.0 (1.0–4.0) 0.004
Systemic corticosteroid use (n, %)a 132 (19.0) 60 (44.1) 72 (12.9) < 0.001
Coinfection with other pathogens (n, %)a 265 (38.2) 84 (61.8) 181 (32.5) < 0.001
  1. aVariables cited in the table above were the candidates which were entered into the multivariate logistic regression model. The bolded values are p-values < 0.05, which represent significant differences between survival group and deceased group. IQR Interquartile range, BMI Body mass index, COPD Chronic obstructive pulmonary disease, SBP Systolic blood pressure, Hb Hemoglobin, BG Blood glucose, ALB Albumin, BUN Blood urea nitrogen, pO2/FiO2 Arterial pressure of oxygen/fraction of inspiration oxygen, NAIs Neuraminidase inhibitors; a: Neuraminidase inhibitor refers to any dose of oseltamivir, zanamivir or peramivir