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Table 3 Factors associated with severe/critically ill in patients with COVID-19: Results from logistic regression analysis

From: Clinical characteristics and risk factors of patients with severe COVID-19 in Jiangsu province, China: a retrospective multicentre cohort study

 

Univariate analysisa

Multivariate analysisb

Variables

Odds ratio (95%CI)

P-value

Odds ratio (95%CI)

P-value

Age (year)

1.07(1.05,1.09)

<.0001

1.06(1.03,1.09)

<.0001

Single onset

1.80(1.05,3.06)

0.0311

0.92(0.43,1.96)

0.8275

Fever

2.42(1.26,4.64)

0.0078

1.50(0.64,3.54)

0.3542

Cough

1.91(1.10,3.33)

0.0216

1.24(0.54,2.87)

0.6110

Sputum

1.91(1.12,3.27)

0.0183

1.12(0.48,2.60)

0.7994

Hypertension

2.87(1.59,5.18)

0.0005

1.06(0.47,2.40)

0.8874

Diabetes

3.28(1.52,7.07)

0.0025

1.64(0.52,5.22)

0.4004

Temperature (°C)

1.59(1.15,2.19)

0.0046

0.95(0.61,1.47)

0.8133

Lymphocyte (109/L)

0.03(0.01,0.08)

<.0001

0.25(0.08,0.74)

0.0161

Platelet (109/L)

0.99(0.98,0.99)

0.0003

1.00(0.99,1.00)

0.5147

Albumin (g/L)

0.91(0.87,0.96)

0.0002

0.99(0.92,1.07)

0.8344

C-reactive protein (mg/L)

1.02(1.01,1.02)

<.0001

1.00(0.99,1.01)

0.9789

Fibrinogen (g/L)

1.87(1.50,2.32)

<.0001

1.04(0.72,1.49)

0.8327

D-dimer (mg/L)

1.28(1.06,1.55)

0.0088

1.17(0.83,1.66)

0.3625

Quadrant score (1–4)

2.28(1.71,3.05)

<.0001

0.90(0.56,1.47)

0.6811

Pulmonary opacity (per 5%)

1.38(1.28,1.49)

<.0001

1.31(1.15,1.51)

0.0001

  1. aUnivariate analysis is based on the complete cases without missing value
  2. bMultivariate analysis is based on imputed values for missing data in Lymphocyte, Platelet, Albumin, C-reactive protein, Fibrinogen, D-dimer, Quadrant score and Pulmonary opacity using multiple imputation method