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Table 3 Characteristics and clinical outcomes of patients treated with long-duration and short-duration antibiotic in the phase 1 study

From: Microbial epidemiology and risk factors for relapse in gram-negative bacteria catheter-related bloodstream infection with a pilot prospective study in patients with catheter removal receiving short-duration of antibiotic therapy

Characteristics and outcomes

Long-duration group (N = 110)

Short-duration group (N = 30)

p-value

Characteristics

 Age (years)

66 (18–95)

74 (28–97)

0.064

 Sex

  Male

59 (53.6%)

19 (63.3%)

0.410

  Female

51 (46.4%)

11 (36.7%)

0.410

 Charlson comorbidity index (score)

6 (0–14)

6 (0–14)

0.383

 Underlying diseases

  HIV infection

1 (0.9%)

0 (0.0%)

1.000

  Cancer

27 (24.5%)

12 (40.0%)

0.110

  Liver disease

7 (6.4%)

3 (10.0%)

0.446

  Renal disease

49 (44.5%)

5 (16.7%)

0.006a

  COPD

4 (3.6%)

3 (10.0%)

0.169

  Diabetes mellitus

42 (38.2%)

7 (23.3%)

0.194

  Hematological disease

9 (8.2%)

3 (10.0%)

0.720

  Cardiovascular disease

23 (20.9%)

5 (16.7%)

0.798

  Trauma

3 (2.7%)

2 (6.7%)

0.291

 Immunocompromised status

22 (20.0%)

10 (33.3%)

0.143

 Microbial etiology

  Monomicrobial

106 (96.4%)

27 (90.0%)

0.169

  Polymicrobial

4 (3.6%)

3 (10.0%)

0.169

Origin of infection

  Healthcare-associated

31 (28.2%)

0 (0.0%)

< 0.001a

  Nosocomial

79 (71.8%)

30 (100.0%)

< 0.001a

 ICU admission at onset of infection

49 (44.5%)

22 (73.3%)

0.007a

 Surgery at present admission

57 (51.8%)

19 (63.3%)

0.305

 Type of catheter

  Tunneled hemodialysis catheter

31 (28.2%)

1 (3.3%)

0.003a

  Short-term central venous catheter or arterial catheter

58 (52.7%)

23 (76.7%)

0.022a

  Long-term central venous catheter or port

21 (19.1%)

6 (20.0%)

1.000

 Catheter management

  Catheter retention

9 (8.2%)

2 (6.7%)

1.000

  Catheter removal

101 (91.8%)

28 (93.3%)

1.000

 Total duration of therapy (day)

17 (14–39)

10 (7–13)

< 0.001a

 Duration of therapy after catheter removal (day)

15 (1–28)

8 (3–13)

< 0.001a

Outcome

 Relapse

7 (6.4%)

2 (6.7%)

1.000

 Deathb

19 (17.3%)

15 (50.0%)

0.001a

 Time to next antibiotic use (hour)

233.3 (54.0–960.0)

392.5 (102.0–504.0)

0.268

 Indication of next antibiotic used

  New infectious episode

13 (11.8%)

2 (6.7%)

0.413

  Non-infectious episode

1 (0.9%)

1 (3.3%)

0.384

  Relapse

6 (5.5%)

2 (6.7%)

1.000

  Undetermined episode

6 (5.5%)

2 (6.7%)

1.000

  1. ap-value < 0.05
  2. bEleven patients in the short-duration and 8 patients in the long-duration group died during treatment
  3. Abbreviations: HIV human immunodeficiency virus, COPD chronic obstructive pulmonary disease, ICU intensive care unit
  4. Data were presented as frequency (percent) except for age, Charlson comorbidity index, total duration of therapy, duration of therapy after catheter removal, and time to next antibiotic use, which were presented as median (minimum-maximum)