Characteristics and outcomes | Long-duration group (N = 110) | Short-duration group (N = 30) | p-value |
---|---|---|---|
Characteristics | |||
Age (years) | 66 (18–95) | 74 (28–97) | 0.064 |
Sex | |||
Male | 59 (53.6%) | 19 (63.3%) | 0.410 |
Female | 51 (46.4%) | 11 (36.7%) | 0.410 |
Charlson comorbidity index (score) | 6 (0–14) | 6 (0–14) | 0.383 |
Underlying diseases | |||
HIV infection | 1 (0.9%) | 0 (0.0%) | 1.000 |
Cancer | 27 (24.5%) | 12 (40.0%) | 0.110 |
Liver disease | 7 (6.4%) | 3 (10.0%) | 0.446 |
Renal disease | 49 (44.5%) | 5 (16.7%) | 0.006a |
COPD | 4 (3.6%) | 3 (10.0%) | 0.169 |
Diabetes mellitus | 42 (38.2%) | 7 (23.3%) | 0.194 |
Hematological disease | 9 (8.2%) | 3 (10.0%) | 0.720 |
Cardiovascular disease | 23 (20.9%) | 5 (16.7%) | 0.798 |
Trauma | 3 (2.7%) | 2 (6.7%) | 0.291 |
Immunocompromised status | 22 (20.0%) | 10 (33.3%) | 0.143 |
Microbial etiology | |||
Monomicrobial | 106 (96.4%) | 27 (90.0%) | 0.169 |
Polymicrobial | 4 (3.6%) | 3 (10.0%) | 0.169 |
Origin of infection | |||
Healthcare-associated | 31 (28.2%) | 0 (0.0%) | < 0.001a |
Nosocomial | 79 (71.8%) | 30 (100.0%) | < 0.001a |
ICU admission at onset of infection | 49 (44.5%) | 22 (73.3%) | 0.007a |
Surgery at present admission | 57 (51.8%) | 19 (63.3%) | 0.305 |
Type of catheter | |||
Tunneled hemodialysis catheter | 31 (28.2%) | 1 (3.3%) | 0.003a |
Short-term central venous catheter or arterial catheter | 58 (52.7%) | 23 (76.7%) | 0.022a |
Long-term central venous catheter or port | 21 (19.1%) | 6 (20.0%) | 1.000 |
Catheter management | |||
Catheter retention | 9 (8.2%) | 2 (6.7%) | 1.000 |
Catheter removal | 101 (91.8%) | 28 (93.3%) | 1.000 |
Total duration of therapy (day) | 17 (14–39) | 10 (7–13) | < 0.001a |
Duration of therapy after catheter removal (day) | 15 (1–28) | 8 (3–13) | < 0.001a |
Outcome | |||
Relapse | 7 (6.4%) | 2 (6.7%) | 1.000 |
Deathb | 19 (17.3%) | 15 (50.0%) | 0.001a |
Time to next antibiotic use (hour) | 233.3 (54.0–960.0) | 392.5 (102.0–504.0) | 0.268 |
Indication of next antibiotic used | |||
New infectious episode | 13 (11.8%) | 2 (6.7%) | 0.413 |
Non-infectious episode | 1 (0.9%) | 1 (3.3%) | 0.384 |
Relapse | 6 (5.5%) | 2 (6.7%) | 1.000 |
Undetermined episode | 6 (5.5%) | 2 (6.7%) | 1.000 |