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Table 4 Factors associated with 12 month estimated glomerular filtration rates in HIV positive adults in Ethiopia. Values are from univariate and multivariate linear regression with coefficient B, 95% confidence interval (CI) and P value

From: Renal function in Ethiopian HIV-positive adults on antiretroviral treatment with and without tenofovir

  Univariate Multivariate
  B (95%CI) P B (95%CI) P
Age, y
 18–25    
 26–35 −8.4 (− 12.4; − 4.5) < 0.001 −5.5 (− 9.5; − 1.4) 0.008+
 36–45 − 14.6 (− 19.3; − 9.9) < 0.001 − 9.7 (− 14.6; − 4.7) < 0.001+
  > 45 −22.6 (− 28.7; − 16.5) < 0.001 − 15.4 (− 22.1; − 8.7) < 0.001+
 Sex, Female 1.7 (− 1.9; 5.2) 0.36
Baseline characteristics
 Body mass index, kg/m2 −0.2 (− 0.9; 0.4) 0.66
 Fat mass index, kg/m2 −0.3 (− 1.2; 0.5) 0.46  
 Fat free mass index, kg/m2 −0.2 (− 1.2; 0.8) 0.72
 Hypertension, Yes 0.01 (− 6; 6) 0.99
 C-reactive protein, mg/L −0.01 (− 0.1; 0.07) 0.99
 CD4 count, cells/ul 0.002 (−0.01; 0.02) 0.83
 On tuberculosis treatment, Yes −1.8 (− 7.5; 3.9) 0.53
 Hepatitis B surface antigen positive, Yes 4.2 (− 5.3; 13.8) 0.38
 Hepatitis C virus antibody Positive, Yes 0.5 (−26.2; 27.3) 0.97
 Viral load, log (copies+ 1/mL) 0.3 (−1.4; 2.1) 0.68
 eGFR, ml/min/1.73 m2 0.3 (0.23; 0.38) < 0.001 0.2 (0.1; 0.3) < 0.001+
Six month change
 Change in body mass index, kg/m2 0.1 (−1; 1.2) 0.87
 Change in fat mass index, kg/m2 −0.4 (−1.8; 1) 0.58
 Change in fat free mass index, kg/m2 0.8 (−1; 2.6) 0.37
 Change in CD4 count, cells/ul 0.03 (0.01; 0.05) < 0.001 0.01 (−0.005; 0.02) 0.18+
 Viral load > 1000 copies/ml at 6 months, Yes −15.1 (−23.4; −6.8) < 0.001 −9.9 (− 17.2; − 2.5) 0.009+
Antiretroviral treatment
 TDF Treatment −2.5 (−7; 2) 0.28 0.2 (−3.8; 4.2) 0.93*
  1. + Variables in one model
  2. * Value are after adjustment for all variables that were included in multivariate model