Table 1 Characteristics of cancer patients with Enterobacteriaceae isolation. Derivation Phase
Total, No. (%) | Cases (ESBL-PE)n = 265 (37) | Controls (non-ESBL-PE)n = 445 (63) | p |
|---|---|---|---|
Clinical characteristics | |||
Age, median (IQR), years | 56 (39–67) | 60 (47–70) | 0.009 |
Age ≥ 70 years | 49 (18) | 114 (25) | 0,029 |
Men | 148 (56) | 286 (64) | 0.026 |
Admission as an outpatient | 231 (87) | 425 (96) | 0.000 |
Solid tumor | 186 (70) | 336 (76) | 0.120 |
Hematological malignancy | 79 (30) | 109 (34) | |
Active neoplasia | 245 (92) | 428 (96) | 0.031 |
Neoplasia in remission | 20 (8) | 17 (4) | |
Comorbidities | |||
Acute myocardial infarction | 6 (1,5) | 7 (2,2) | 0,050 |
Symptomatic heart failure | 5 (1,8) | 9 (2) | 0,900 |
Peripheral arterial disease | 1 (0,38) | 1 (0,22) | 0,711 |
Cerebrovascular disease | 2 (0,7)) | 3 (0,6)) | 0,901 |
Dementia | 2 (0,7) | 4 (0,9) | 0,839 |
Chronic obstructive pulmonary disease | 14 (5,2) | 18 (4,0) | 0,442 |
Connective tissue disease | 2 (0,7) | 8 (1,8) | 0,254 |
Peptic acid disease | 2 (0,7) | 3 (0,6) | 0,901 |
Chronic liver disease | 5 (1,8) | 6 (1,3) | 0,574 |
Mellitus diabetes | 18 (6,7) | 44 (9,8) | 0,158 |
Hemiplegia | 9 (3,4) | 12 (2,7) | 0,595 |
Renal disease | 20 (7,5) | 28 (6,2) | 0,519 |
Metastasis | 85 (32) | 135 (30) | 0,628 |
AIDS | 4 (1,5) | 3 (0,6) | 0,276 |
Charlson comorbidity index ≥4 | 104 (39) | 167 (36) | 0,649 |
Medical interventions | |||
Hospitalization during previous year | 223 (84) | 264 (59) | 0.000 |
Prolonged hospitalization (≥7 days) | 119 (45) | 141 (32) | 0.000 |
Immunosuppressive therapya | 27 (10) | 19 (4) | 0,002 |
Radiation therapya | 23 (9) | 43 (10) | 0.662 |
Chemotherapya | 89 (34) | 183 (41) | 0.046 |
Neutropenia at the time of culture | 59 (22) | 68 (15) | 0.019 |
Surgical procedures during previous year | 130 (49) | 168 (38) | 0.003 |
Invasive devices at the time of cultureb | 146 (55) | 177 (40) | 0.000 |
Urinary catheter during last month | 93 (35) | 127 (29) | 0,068 |
Antibiotic use during previous month to index culture | |||
Any antibiotic | 102 (38) | 108 (24) | 0,000 |
Beta-lactams | 80 (31) | 82 (18) | 0,000 |
Aminoglycosides | 5 (2) | 2 (0,4) | 0,108 |
Quinolones | 10 (3,8) | 8 (1,8) | 0,136 |
Carbapenemic | 26 (10) | 16 (3,6) | 0,001 |
Cotrimoxazole | 11 (4) | 7 (1,5) | 0,045 |
Others | 21 (8) | 23 (5) | 0,125 |
Isolate source | |||
Blood | 63 (23) | 86 (19) | 0.384 |
Urinary tract | 142 (54) | 272 (61) | |
Surgical wound | 47 (18) | 68 (15) | |
Skin and soft tissues | 3 (1) | 4 (1) | |
Lower respiratory tract | 10 (4) | 15 (3) | |
Isolated microorganism | |||
E. coli. | 166 (63) | 299 (67) | 0.000 |
Klebsiella spp. | 92 (35) | 80 (18) | |
Proteus spp. | 3 (1) | 55 (12) | |
Others | 4 (2) | 11 (2) | |