Skip to main content

Table 1 Characteristics of cancer patients with Enterobacteriaceae isolation. Derivation Phase

From: Development and validation of a scoring system for predicting cancer patients at risk of extended-spectrum b-lactamase-producing Enterobacteriaceae infections

Total, No. (%) Cases
(ESBL-PE)n = 265 (37)
Controls
(non-ESBL-PE)n = 445 (63)
p
Clinical characteristics
 Age, median (IQR), years 56 (39–67) 60 (47–70) 0.009
 Age ≥ 70 years 49 (18) 114 (25) 0,029
 Men 148 (56) 286 (64) 0.026
 Admission as an outpatient 231 (87) 425 (96) 0.000
 Solid tumor 186 (70) 336 (76) 0.120
 Hematological malignancy 79 (30) 109 (34)
 Active neoplasia 245 (92) 428 (96) 0.031
 Neoplasia in remission 20 (8) 17 (4)
Comorbidities
 Acute myocardial infarction 6 (1,5) 7 (2,2) 0,050
 Symptomatic heart failure 5 (1,8) 9 (2) 0,900
 Peripheral arterial disease 1 (0,38) 1 (0,22) 0,711
 Cerebrovascular disease 2 (0,7)) 3 (0,6)) 0,901
 Dementia 2 (0,7) 4 (0,9) 0,839
 Chronic obstructive pulmonary disease 14 (5,2) 18 (4,0) 0,442
 Connective tissue disease 2 (0,7) 8 (1,8) 0,254
 Peptic acid disease 2 (0,7) 3 (0,6) 0,901
 Chronic liver disease 5 (1,8) 6 (1,3) 0,574
 Mellitus diabetes 18 (6,7) 44 (9,8) 0,158
 Hemiplegia 9 (3,4) 12 (2,7) 0,595
 Renal disease 20 (7,5) 28 (6,2) 0,519
 Metastasis 85 (32) 135 (30) 0,628
 AIDS 4 (1,5) 3 (0,6) 0,276
 Charlson comorbidity index ≥4 104 (39) 167 (36) 0,649
Medical interventions
 Hospitalization during previous year 223 (84) 264 (59) 0.000
 Prolonged hospitalization (≥7 days) 119 (45) 141 (32) 0.000
 Immunosuppressive therapya 27 (10) 19 (4) 0,002
 Radiation therapya 23 (9) 43 (10) 0.662
 Chemotherapya 89 (34) 183 (41) 0.046
 Neutropenia at the time of culture 59 (22) 68 (15) 0.019
 Surgical procedures during previous year 130 (49) 168 (38) 0.003
 Invasive devices at the time of cultureb 146 (55) 177 (40) 0.000
 Urinary catheter during last month 93 (35) 127 (29) 0,068
Antibiotic use during previous month to index culture
 Any antibiotic 102 (38) 108 (24) 0,000
 Beta-lactams 80 (31) 82 (18) 0,000
 Aminoglycosides 5 (2) 2 (0,4) 0,108
 Quinolones 10 (3,8) 8 (1,8) 0,136
 Carbapenemic 26 (10) 16 (3,6) 0,001
 Cotrimoxazole 11 (4) 7 (1,5) 0,045
 Others 21 (8) 23 (5) 0,125
Isolate source
 Blood 63 (23) 86 (19) 0.384
 Urinary tract 142 (54) 272 (61)
 Surgical wound 47 (18) 68 (15)
 Skin and soft tissues 3 (1) 4 (1)
 Lower respiratory tract 10 (4) 15 (3)
Isolated microorganism
E. coli. 166 (63) 299 (67) 0.000
Klebsiella spp. 92 (35) 80 (18)
Proteus spp. 3 (1) 55 (12)
 Others 4 (2) 11 (2)
  1. a during the previous 3 months, bcentral venous catheter, dialysis catheter, surgical drains, bladder catheter, nephrostomy, nasogastric tube