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Table 1 Summary of cases of infections caused by S. saccharolyticus

From: An unusual Staphylococcus saccharolyticus spondylodiscitis post kyphoplasty: a case report

Year (ref)

Location

Age/Sex

Diagnosis

Risk factors

Comment on clinical presentation

Biology

Microbiological diagnosis

Antimicrobial susceptibility

Final treatment (total duration)

Outcome

1990 [4]

USA

61/M

Endocarditis

No predisposing valvular heart disease

Low grade fever at onset; moderate-sized mitral valve vegetation

Anemia; thrombocytosis; ESR elevation

BC; all bottles positive at day 10

Susceptible to PE, OX, VA, GE, CI, CL; resistant to ME

NAF + GE (6 wks)

Favorable at day 30

1996 [9]

USA

57/W

Prosthetic mitral valve endocarditis

NA

Fever; large masses at prosthetic valve level

Anemia; hyperleukocytosis

BC; all anaerobic vials positive at day 1; aerobic vials positive at day 11

Susceptible to VA, CL, CH; resistant to all β-lactamin agents (including OX, CES, ME, TET)

Valve change; medical treatment (NA)

Died at day 32 of hospitalization

2009 [10]

USA

NA

Prosthetic valve endocarditis

NA

NA

NA

Mitral valve; anaerobic culture; at day NA

NA

NA

NA

1990 [11]

China

21/M

Pneumonia

NA

Blood-stained sputum; multiple spherical focal lesions in the lung (CT scan)

Anemia; hyperleukocytosis

NA

Susceptible to LE, MO; NA for other antibiotics

AZ (6 d); TI + PE (3 d); IM + TI (1 d)

Died at day 120 of hospitalization

2015 [12]

China

26/W

Bone marrow infection

NA

High-grade fever; headache at onset; lymph nodes

Anemia; hyperleukocytosis; ESR and CRP strong elevation

Lung biopsy; positive anaerobic culture at day 10?

Susceptible to VA, LE, PE, CL; resistant to ME;

PE + VA (2 d); IM + VA (NA)

Died at day 114

2005 [2]

France

58/M

Spondylodiscitis

No endocarditis; no underlying disease but poor oral hygiene

Thoracic posterior pains for 2 months; fever; weight loss; NSAIDs/corticosteroids treatment

At admission, hyperleukocytosis; ESR and CRP elevation

BC and bone marrow; positive anaerobic cultures at day 3

Susceptible to VA, TEI, RI, ER, PR, TET, OF, CL; Resistant to ME; No β-lactamase production; no mecA gene

OF+CL (12 wks)

Favorable at year 1

2009 [3]

USA

38/M

Spondylodiscitis

NA

Radicular symptoms treated unsuccessfully by microdiscectomy

Elevation of inflammatory parameters

Negative aerobic cultures; negative acid-fast bacilli

NA

NA

NA

2017 [5]

NZ

48/M

Pyomyositis, spermatic cord infection

Type II diabetes; hyperlipidemia

Fever

Neutrophilia; CRP large increase; CPK normal

Multiple muscle biopsies; anaerobic positive culture at 24 h; coinfection S. capitis and S. saccharolyticus

Susceptible to FL; Resistant to PE

CEFA (1 wk); CEP (2 wks)

Favorable at 4 weeks

2017 (our case)

France

57/M

Spondylodiscitis

Heavy smoking; alcoholism; unhealthy underweight

Vertebral fractures (treated by kyphoplasty and zygapophyseal joint steroid injection); no fever; unremarkable clinical examination

Hyperleukocytosis; CRP moderate increase

Aerobic cultures negative at day 7

Susceptible to PE; CEF, MA, RI, TET, FO, OF; no β-lactamase production

AM (4 wks)

Favorable at 46 months

  1. M man, W woman, ESR erythrocyte sedimentation rate, BC blood culture, NA non-available, AM amoxicillin, AZ azithromycin, CEFA cefazolin, CEF cefoxitin, CEP cephalexin, CES cephalosporin, CH chloramphenicol, CI ciprofloxacin, CL clindamycin, ER erythromycin, FL flucloxacillin, FO fosfomycin, GE gentamicin, IM imipenem, LE levofloxacin, MA macrolides, ME metronidazole, MO moxifloxacin, NAF nafcillin, OF ofloxacin, OX oxacillin, PE penicillin, PR pristinamycin, RI rifampicin, TEI teicoplanin, TET tetracycline, TI timidazole, VA vancomycin