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Table 1 Pfdhfr and Pfdhps haplotypes

From: Occurrence of septuple and elevated Pfdhfr-Pfdhps quintuple mutations in a general population threatens the use of sulfadoxine-pyrimethamine for malaria prevention during pregnancy in eastern-coast of Tanzania

Gene Haplotype Frequency (n) Percentage (%)
Pfdhfr(n = 445) NCSI 6 1.3
I*** 1 0.2
ICNI 30 6.7
INI* 5 1.1
IR** 5 1.1
IRNI 374 84.0
NI** 1 0.2
NR** 1 0.2
NRNI 22 4.9
Pfdhps(n = 446) SAKAA 30 6.7
AAAA* 1 0.2
AAKAA 6 1.3
AGEAA 6 1.3
AGKGS 1 0.2
FGKAA 1 0.2
GEAA* 2 0.4
HAKAA 2 0.4
SAAA* 1 0.2
SAEAA 3 0.7
SEAA* 3 0.7
SG*** 2 0.4
SGAA* 5 1.1
SGE** 6 1.3
SGEA* 1 0.2
SGEAA 370 83.0
SGEGA 4 0.9
SGKAA 2 0.4
  1. *Indicates missing genotype(s) during sequencing. Each letter represents an amino acid, A alanine, C cysteine, E Glutamic acid, F Phenylalanine, G Glycine, H Histidine, I Isoleucine, K Lysine, N Asparagine, R arginine, S Serine. Bold underline represent amino acid changes. SAKAA and NCSI represent the wildtype (WT) amino acids for Pfdhps and Pfdhfr, respectively