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Table 3 Univariable analysis of factors associated with 30-day mortality of surgical patients with candidemia

From: Epidemiology, species distribution, and predictive factors for mortality of candidemia in adult surgical patients

Variable Survivors n = 139 (80.8%) Deaths n = 33 (19.2%) Odds ratio 95% Confidence interval P value
Age 61.6 ± 14.4 66.5 ± 12.6 1.03 1–1.06 0.07
Age ≥ 65 years 57 (41.0%) 18 (54.5%) 1.73 0.8–3.71 0.16
Male sex 97 (69.8%) 22 (66.7%) 0.87 0.39–1.95 0.73
Underlying diseases
 Solid tumors 77 (55.4%) 13 (39.4%) 0.52 0.24–1.14 0.10
 Diabetes mellitus 24 (17.3%) 8 (24.2%) 1.53 0.62–3.81 0.36
Predisposing factors
 Current and former smokers 42 (30.2%) 10 (30.3%) 1 0.44–2.29 0.99
 ICU stay 38 (27.3%) 25 (75.8%) 8.31 3.45–20.01 < 0.001
 Recent abdominal surgery 118 (84.9%) 23 (69.7%) 0.41 0.17–0.98 0.046
 Recent cancer surgery 74 (53.2%) 11 (33.3%) 0.44 0.2–0.97 0.04
 Prior antibiotics exposure 134 (96.4%) 32 (97.0%) 1.19 0.13–10.58 0.87
 Prior antifungal exposure 20 (14.4%) 5 (15.2%) 1.06 0.37–3.08 0.91
 TPN 130 (93.5%) 32 (97.0%) 2.22 0.27–18.13 0.46
 Presence of CVC 49 (35.3%) 18 (54.5%) 2.2 1.02–4.75 0.04
 Mechanical ventilation 15 (10.8%) 5 (15.2%) 1.48 0.5–4.4 0.48
 Presence of urinary catheter 106 (76.3%) 21 (63.6%) 0.54 0.24–1.22 0.14
 Presence of gastric tube 109 (78.4%) 23 (69.7%) 0.63 0.27–1.47 0.29
Laboratory findings
 Renal failure 17 (12.2%) 14 (42.4%) 5.29 2.24–12.46 < 0.001
 Anemia 116 (83.5%) 28 (84.8%) 1.11 0.39–3.18 0.85
 Hypoalbuminemia 47 (33.8%) 24 (72.7%) 5.22 2.25–12.13 < 0.001
 Hyponatremia 67 (48.2%) 6 (18.2%) 0.24 0.09–0.61 0.003
 Leukopenia 14 (10.1%) 5 (15.2%) 1.59 0.53–4.79 0.41
 Thrombocytopenia 10 (7.2%) 14 (42.4%) 9.51 3.7–24.42 < 0.001
C. albicans infection 39 (28.1%) 19 (57.6%) 3.48 1.59–7.62 0.002
C. parapsilosis infection 67 (48.2%) 7 (21.2%) 0.29 0.12–0.71 0.007
C. glabrata infection 15 (10.8%) 4 (12.1%) 1.14 0.35–3.69 0.83
C. tropicalis infection 11 (7.9%) 3 (9.1%) 1.16 0.31–4.43 0.82
 Fluconazole susceptibility 103 (74.1%) 23 (69.7%) 0.8 0.35–1.85 0.61
Empirical antifungal therapy 94 (67.6%) 21 (63.6%) 0.84 0.38–1.85 0.66
No antifungal therapy 22 (15.8%) 5 (15.2%) 0.95 0.33–2.73 0.92
Outcome
 LOS (days) 33 (22–48) 31 (23–41.5) 1 0.98–1.01 0.52
  1. ICU, Intensive care unit; TPN, Total parenteral nutrition; CVC, central venous catheter; LOS, Length of hospital stay;