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Table 2 In vitro antifungal susceptibility of Candida species isolated from surgical patients with candidemia

From: Epidemiology, species distribution, and predictive factors for mortality of candidemia in adult surgical patients

Species Antifungal agent MIC (μg/ml) No. (%) of isolates by new CBPsa
(n = 172)   Ranges MIC50 MIC90 S SDD / I R
C. albicans (n = 58) Fluconazole ≤0.5–16 ≤1 4 50 (86.2%) 6 (10.3%) 2 (3.4%)
Voriconazole ≤0.03- ≤ 4 0.06 ≤1 49 (84.5%) 3 (5.2%) 6 (10.3%)
Itraconazole 0.062–1 ≤0.125 0.25 NA NA NA
Amphotericin B ≤0.25–1 ≤0.5 0.5 58 (100%) 0 0
C. parapsilosis (n = 74) Fluconazole ≤0.5–8 ≤1 ≤4 65 (87.8%) 8 (10.8%) 1 (1.4%)
Voriconazole ≤0.03–0.25 ≤0.06 0.125 72 (97.3%) 2 (2.7%) 0
Itraconazole ≤0.062–0.25 ≤0.125 0.125 72 (97.3%) 0 2 (2.7%)
Amphotericin B ≤0.25–1 ≤0.5 0.5 74 (100%) 0 0
C. glabrata (n = 19) Fluconazole ≤1–16 4 16 0 19 (100%) 0
Voriconazole ≤0.06–0.5 0.125 0.25 NA NA NA
Itraconazole ≤0.125–1 0.25 1 NA NA NA
Amphotericin B ≤0.25–1 ≤0.5 0.5 19 (100%) 0 0
C. tropicalis (n = 14) Fluconazole ≤1–32 1 16 11 (78.6%) 1 (7.1%) 2 (14.3%)
Voriconazole ≤0.06–4 0.06 0.5 12 (85.7%) 1 (7.1%) 1 (7.1%)
Itraconazole ≤0.125–8 0.125 1 10 (71.4%) 0 4 (28.6%)
Amphotericin B ≤0.25–0.5 ≤0.5 0.5 14 (100%) 0 0
C. kruseib (n = 1) Fluconazole 64    0 0 1 (100%)
Voriconazole 0.5    1 (100%) 0 0
Itraconazole 1    NA NA NA
Amphotericin B 1    1 (100%) 0 0
Others (n = 6) Fluconazole ≤1–16 ≤2 16 NA NA NA
Voriconazole ≤0.06–2 ≤0.06 2 NA NA NA
Itraconazole ≤0.125–1 0.125 1 NA NA NA
Amphotericin B ≤0.5–0.5 ≤0.5 0.5 NA NA NA
  1. a Specific clinical breakpoints (CBPs) for Candida susceptibility to fluconazole and voriconazole were determined following CLSI [14], while CBPs for susceptibility of Candida against itraconazole and amphotericin B were obtained from EUCAST [15]; b Minimum inhibitory concentration (MIC) 50 and MIC 90 values were not calculated for antifungal drugs against C. krusei owing to the small number of C. krusei case. Isolates of C. krusei are assumed to be intrinsically resistant to fluconazole. S, susceptible; I, intermediate; SDD, susceptible-dose dependent; R, resistant; NA, non-applicable;