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Table 1 Demographics and clinical characteristics of surgical and non-surgical patients with candidemia

From: Epidemiology, species distribution, and predictive factors for mortality of candidemia in adult surgical patients

Characteristics Surgical patients (n = 172) Non-surgical patients (n = 64) P value
Age 62.5 ± 14.2 55.0 ± 21.9 0.002
Age ≥ 65 years 75 (43.6%) 22 (34.4%) 0.2
Male sex 119 (69.2%) 41 (64.1%) 0.45
Underlying diseases
 Hematological malignancy 1 (0.6%) 15 (23.4%) < 0.001
 Solid tumors 90 (52.3%) 8 (12.5%) < 0.001
 Diabetes mellitus 32 (18.6%) 24 (37.5%) 0.002
Predisposing factors
 Renal replacement therapy 7 (4.1%) 15 (23.4%) < 0.001
 Current and former smokers 52 (30.2%) 18 (28.1%) 0.75
 ICU stay 63 (36.6%) 20 (31.3%) 0.44
 Prior antibiotics exposure 166 (96.5%) 52 (81.3%) < 0.001
 Prior antifungal exposure 25 (14.5%) 12 (18.8%) 0.43
 TPN 162 (94.2%) 26 (40.6%) < 0.001
 Presence of CVC 67 (39.0%) 26 (40.6%) 0.82
 Mechanical ventilation 20 (11.6%) 8 (12.5%) 0.85
 Presence of urinary catheter 127 (73.8%) 21 (32.8%) < 0.001
 Presence of gastric tube 132 (76.7%) 23 (35.9%) < 0.001
Laboratory findings
 Renal failure 31 (18%) 26 (40.6%) < 0.001
 Anemia 144 (83.7%) 55 (85.9%) 0.68
 Hypoalbuminemia 71 (41.3%) 31 (48.4%) 0.32
 Hyponatremia 73 (42.4%) 18 (28.1%) 0.045
 Leukopenia 19 (11%) 19 (29.7%) 0.001
 Thrombocytopenia 24 (14.0%) 24 (37.5%) < 0.001
C. albicans infection 58 (33.7%) 25 (39.1%) 0.45
C. parapsilosis infection 74 (43.0%) 15 (23.4%) 0.006
C. glabrata infection 19 (11%) 10 (15.6%) 0.34
C. tropicalis infection 14 (8.1%) 13 (20.3%) 0.009
 Fluconazole susceptibility 126 (73.3%) 44 (68.8%) 0.50
Empirical antifungal therapy 115 (66.9%) 40 (62.5%) 0.53
No antifungal therapy 27 (15.7%) 9 (14.1%) 0.76
Outcome
 30-day mortality 33 (19.2%) 18 (28.1%) 0.14
 LOS (days) 32 (22.3–47.8) 26 (15–47) 0.02
  1. ICU, Intensive care unit; TPN, Total parenteral nutrition; CVC, central venous catheter; LOS, Length of hospital stay;