Table 1 Demographics and clinical characteristics of surgical and non-surgical patients with candidemia
Characteristics | Surgical patients (n = 172) | Non-surgical patients (n = 64) | P value |
|---|---|---|---|
Age | 62.5 ± 14.2 | 55.0 ± 21.9 | 0.002 |
Age ≥ 65 years | 75 (43.6%) | 22 (34.4%) | 0.2 |
Male sex | 119 (69.2%) | 41 (64.1%) | 0.45 |
Underlying diseases | |||
 Hematological malignancy | 1 (0.6%) | 15 (23.4%) | < 0.001 |
 Solid tumors | 90 (52.3%) | 8 (12.5%) | < 0.001 |
 Diabetes mellitus | 32 (18.6%) | 24 (37.5%) | 0.002 |
Predisposing factors | |||
 Renal replacement therapy | 7 (4.1%) | 15 (23.4%) | < 0.001 |
 Current and former smokers | 52 (30.2%) | 18 (28.1%) | 0.75 |
 ICU stay | 63 (36.6%) | 20 (31.3%) | 0.44 |
 Prior antibiotics exposure | 166 (96.5%) | 52 (81.3%) | < 0.001 |
 Prior antifungal exposure | 25 (14.5%) | 12 (18.8%) | 0.43 |
 TPN | 162 (94.2%) | 26 (40.6%) | < 0.001 |
 Presence of CVC | 67 (39.0%) | 26 (40.6%) | 0.82 |
 Mechanical ventilation | 20 (11.6%) | 8 (12.5%) | 0.85 |
 Presence of urinary catheter | 127 (73.8%) | 21 (32.8%) | < 0.001 |
 Presence of gastric tube | 132 (76.7%) | 23 (35.9%) | < 0.001 |
Laboratory findings | |||
 Renal failure | 31 (18%) | 26 (40.6%) | < 0.001 |
 Anemia | 144 (83.7%) | 55 (85.9%) | 0.68 |
 Hypoalbuminemia | 71 (41.3%) | 31 (48.4%) | 0.32 |
 Hyponatremia | 73 (42.4%) | 18 (28.1%) | 0.045 |
 Leukopenia | 19 (11%) | 19 (29.7%) | 0.001 |
 Thrombocytopenia | 24 (14.0%) | 24 (37.5%) | < 0.001 |
C. albicans infection | 58 (33.7%) | 25 (39.1%) | 0.45 |
C. parapsilosis infection | 74 (43.0%) | 15 (23.4%) | 0.006 |
C. glabrata infection | 19 (11%) | 10 (15.6%) | 0.34 |
C. tropicalis infection | 14 (8.1%) | 13 (20.3%) | 0.009 |
 Fluconazole susceptibility | 126 (73.3%) | 44 (68.8%) | 0.50 |
Empirical antifungal therapy | 115 (66.9%) | 40 (62.5%) | 0.53 |
No antifungal therapy | 27 (15.7%) | 9 (14.1%) | 0.76 |
Outcome | |||
 30-day mortality | 33 (19.2%) | 18 (28.1%) | 0.14 |
 LOS (days) | 32 (22.3–47.8) | 26 (15–47) | 0.02 |