Table 5 Factors associated with NKT cells secreting cytokines in the univariate and multivariate linear regression analysis
Variable | NKT_IFN-γ | NKT_TNF-α | ||||||
|---|---|---|---|---|---|---|---|---|
Univariate (raw effects) | Multivariate (adjusted effects) | Univariate (raw effects) | Multivariate (adjusted effects) | |||||
B (95% CI) | P | Adjusted B (95% CI) | Adjusted P | B (95% CI) | P | Adjusted B (95% CI) | Adjusted P | |
Age (≥ 25 vs < 25 years) | 8.58 (− 0.42, 17.57) | 0.061 | 7.6 (−1.6, 16.79) | 0.105 | 5.92 (− 2.86, 14.7) | 0.185 | 5.08 (−3.41, 13.57) | 0.238 |
Gender (Male ve Female) | 3.26 (−5.24, 11.76) | 0.450 | 1.42 (−7.14, 9.98) | 0.743 | 4.94 (−3.28, 13.16) | 0.237 | 5.15 (−2.75, 13.05) | 0.200 |
Family History (Yes vs No) | −1.76 (−9.48, 5.96) | 0.653 | −4.77 (−13.42, 3.88) | 0.277 | 0.84 (−6.65, 8.33) | 0.824 | −3.09 (−11.07, 4.9) | 0.446 |
Vertical Transmission (Yes vs No) | −1.23 (− 11.73, 9.27) | 0.817 | 2.99 (−8.67, 14.65) | 0.613 | 2.62 (−7.56, 12.8) | 0.611 | 3.87 (−6.9, 14.64) | 0.478 |
Infection Time (≥ 20 vs < 20 years) | 2.34 (− 8.53, 13.22) | 0.671 | −2.54 (−13.8, 8.73) | 0.657 | 4.67 (−5.86, 15.2) | 0.382 | 0.45 (−9.95, 10.85) | 0.931 |
Log HBsAg | 0.24 (−5.89, 6.37) | 0.938 | 0.15 (−6.1, 6.4) | 0.962 | −2.02 (−7.97, 3.91) | 0.501 | −1.35 (−7.12, 4.43) | 0.645 |
Log HBV DNA | −0.031 (−0.06, −0.003) | 0.032 | −3.87 (−7.08, − 0.66) | 0.019 | 0.048 (0.23, 0.073) | 0.000 | −2.01 (−4.98, 0.96) | 0.182 |
HBeAg (Positive vs Negative) | −0.57 (−8.28, 7.15) | 0.885 | 9.48 (−3.38, 22.34) | 0.147 | 7.79 (0.41, 15.17) | 0.039 | 10.69 (−1.19, 22.56) | 0.077 |
ALT (< 2 ULN is the reference group) | ||||||||
  ≥ 2 & < 5 ULN | 17.4 (7.66, 27.15) | 0.001 | 21.4 (10.62, 32.17) | 0.000 | 22.11 (13.17, 31.06) | 0.000 | 22.21 (12.26, 32.16) | 0.000 |
  ≥ 5ULN | 9.89 (−2.25, 22.02) | 0.110 | 13.41 (−0.08, 26.89) | 0.051 | 20.89 (9.76, 32.02) | 0.000 | 18.93 (6.48, 31.38) | 0.003 |
Genotype (Genotype C is the reference group) | ||||||||
 B | −5.71 (−15.36, 3.93) | 0.244 | −3.93 (− 13.51, 5.65) | 0.419 | − 11.45 (−24.03, 1.13) | 0.074 | − 5.67 (− 14.52, 3.17) | 0.207 |
 N | −4.75 (− 17.88, 8.37) | 0.475 | −13.52 (− 29.43, 2.39) | 0.095 | −17.77 (− 33.46, − 2.08) | 0.027 | −11.02 (− 25.71, 3.67) | 0.140 |
 O | − 13.33 (− 29.69, 3.04) | 0.110 | −9.87 (− 26.29, 6.54) | 0.236 | −8.22 (− 17.46, 1.03) | 0.081 | −11.74 (− 26.89, 3.42) | 0.128 |