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Table 5 Factors associated with NKT cells secreting cytokines in the univariate and multivariate linear regression analysis

From: Association among cytokine profiles of innate and adaptive immune responses and clinical-virological features in untreated patients with chronic hepatitis B

Variable NKT_IFN-γ NKT_TNF-α
Univariate (raw effects) Multivariate (adjusted effects) Univariate (raw effects) Multivariate (adjusted effects)
B (95% CI) P Adjusted B (95% CI) Adjusted P B (95% CI) P Adjusted B (95% CI) Adjusted P
Age (≥ 25 vs < 25 years) 8.58 (− 0.42, 17.57) 0.061 7.6 (−1.6, 16.79) 0.105 5.92 (− 2.86, 14.7) 0.185 5.08 (−3.41, 13.57) 0.238
Gender (Male ve Female) 3.26 (−5.24, 11.76) 0.450 1.42 (−7.14, 9.98) 0.743 4.94 (−3.28, 13.16) 0.237 5.15 (−2.75, 13.05) 0.200
Family History (Yes vs No) −1.76 (−9.48, 5.96) 0.653 −4.77 (−13.42, 3.88) 0.277 0.84 (−6.65, 8.33) 0.824 −3.09 (−11.07, 4.9) 0.446
Vertical Transmission (Yes vs No) −1.23 (− 11.73, 9.27) 0.817 2.99 (−8.67, 14.65) 0.613 2.62 (−7.56, 12.8) 0.611 3.87 (−6.9, 14.64) 0.478
Infection Time (≥ 20 vs < 20 years) 2.34 (− 8.53, 13.22) 0.671 −2.54 (−13.8, 8.73) 0.657 4.67 (−5.86, 15.2) 0.382 0.45 (−9.95, 10.85) 0.931
Log HBsAg 0.24 (−5.89, 6.37) 0.938 0.15 (−6.1, 6.4) 0.962 −2.02 (−7.97, 3.91) 0.501 −1.35 (−7.12, 4.43) 0.645
Log HBV DNA −0.031 (−0.06, −0.003) 0.032 −3.87 (−7.08, − 0.66) 0.019 0.048 (0.23, 0.073) 0.000 −2.01 (−4.98, 0.96) 0.182
HBeAg (Positive vs Negative) −0.57 (−8.28, 7.15) 0.885 9.48 (−3.38, 22.34) 0.147 7.79 (0.41, 15.17) 0.039 10.69 (−1.19, 22.56) 0.077
ALT (< 2 ULN is the reference group)
  ≥ 2 & < 5 ULN 17.4 (7.66, 27.15) 0.001 21.4 (10.62, 32.17) 0.000 22.11 (13.17, 31.06) 0.000 22.21 (12.26, 32.16) 0.000
  ≥ 5ULN 9.89 (−2.25, 22.02) 0.110 13.41 (−0.08, 26.89) 0.051 20.89 (9.76, 32.02) 0.000 18.93 (6.48, 31.38) 0.003
Genotype (Genotype C is the reference group)
 B −5.71 (−15.36, 3.93) 0.244 −3.93 (− 13.51, 5.65) 0.419 − 11.45 (−24.03, 1.13) 0.074 − 5.67 (− 14.52, 3.17) 0.207
 N −4.75 (− 17.88, 8.37) 0.475 −13.52 (− 29.43, 2.39) 0.095 −17.77 (− 33.46, − 2.08) 0.027 −11.02 (− 25.71, 3.67) 0.140
 O − 13.33 (− 29.69, 3.04) 0.110 −9.87 (− 26.29, 6.54) 0.236 −8.22 (− 17.46, 1.03) 0.081 −11.74 (− 26.89, 3.42) 0.128
  1. Significant values are shown in boldface. B: Unstandardized Coefficients. HBV genotype: Other included C + D, B + D, B + C, D; N, not detected
  2. ALT alanine aminotransferase, HBeAg HBV e antigen, HBsAg hepatitis B surface antigen;
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