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Table 4 Factors associated with NK cells secreting cytokines in the univariate and multivariate linear regression analysis

From: Association among cytokine profiles of innate and adaptive immune responses and clinical-virological features in untreated patients with chronic hepatitis B

Variable NK_IFN-γ NK_TNF-α
Univariate (raw effects) Multivariate (adjusted effects) Univariate (raw effects) Multivariate (adjusted effects)
B (95% CI) P Adjusted B (95% CI) Adjusted P B (95% CI) P Adjusted B (95% CI) Adjusted P
Age (≥ 25 vs <  25 years) 3.36 (−5.44, 12.16) 0.452 3 (− 5.91, 11.9) 0.507 4.93 (−4.1, 13.97) 0.282 2.84 (−5.53, 11.2) 0.503
Gender (Male ve Female) 0.32 (−7.92, 8.56) 0.939 −1.23 (− 9.52, 7.06) 0.769 1.87 (− 6.61, 10.36) 0.663 1.68 (− 6.11, 9.47) 0.670
Family History (Yes vs No) −0.82 (−8.3, 6.66) 0.829 −3.98 (−12.36, 4.4) 0.349 − 2.24 (− 9.93, 5.45) 0.566 −6.54 (− 14.41, 1.33) 0.103
Vertical Transmission (Yes vs No) − 1.64 (− 11.81, 8.53) 0.750 0.51 (− 10.79, 11.8) 0.929 1.54 (− 8.92, 12.01) 0.771 4.82 (− 5.8, 15.43) 0.371
Infection Time (≥ 20 vs < 20 years) 6.21 (− 4.28, 16.7) 0.244 4.06 (− 6.85, 14.97) 0.463 6.95 (− 3.84, 17.74) 0.205 4.32 (−5.93, 14.57) 0.406
Log HBsAg −0.66 (−6.60, 5.27) 0.825 − 0.72 (− 6.78, 5.33) 0.814 −3.73 (− 9.81, 2.35) 0.227 − 2.55 (− 8.24, 3.14) 0.376
Log HBV DNA 0.024 (− 0.001, 0.048) 0.058 −2.84 (− 5.95, 0.28) 0.074 2.02 (0.50, 3.53) 0.009 − 0.19 (− 3.11, 2.74) 0.899
HBeAg (Positive vs Negative) 2.61 (−4.85, 10.07) 0.490 8.29 (−4.17, 20.75) 0.190 7.08 (−0.53, 14.68) 0.068 1.38 (−10.32, 13.09) 0.816
ALT (< 2 ULN is the reference group)
 ≥ 2 & < 5 ULN 16.73 (7.3, 26.15) 0.001 17.63 (7.19, 28.07) 0.001 25.61 (16.89, 34.33) 0.000 24.39 (14.58, 34.19) 0.000
 ≥ 5ULN 11.45 (−0.27, 23.18) 0.056 11.66 (−1.4, 24.72) 0.080 28.69 (17.84, 39.54) 0.000 27.64 (15.37, 39.91) 0.000
Genotype (Genotype C is the reference group)
 B −6.57 (−15.74, 2.6) 0.159 −5.2 (− 14.47, 4.08) 0.270 −7.33 (− 16.87, 2.22) 0.132 −4.23 (− 12.94, 4.49) 0.339
 N − 10.05 (− 22.53, 2.43) 0.114 − 15.6 (−31.01, − 0.19) 0.047 −10.81 (− 23.8, 2.19) 0.102 − 5.2 (− 19.68, 9.28) 0.479
 O − 22.02 (− 37.59, − 6.46) 0.006 − 20.06 (− 35.96, − 4.15) 0.014 −15.64 (− 31.85, 0.57) 0.058 −9.13 (− 24.07, 5.81) 0.229
  1. Significant values are shown in boldface. B: Unstandardized Coefficients. HBV genotype: Other included C + D, B + D, B + C, D; N, not detected
  2. ALT alanine aminotransferase, HBeAg HBV e antigen, HBsAg, hepatitis B surface antigen;