Table 2 Factors associated with CD4+ T cells secreting cytokines in the univariate and multivariate linear regression analysis
Variable | CD4_IFN-γ | CD4_TNF-α | CD4_IL-2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate (raw effects) | Multivariate (adjusted effects) | Univariate (raw effects) | Multivariate (adjusted effects) | Univariate (raw effects) | Multivariate (adjusted effects) | |||||||
B (95% CI) | P | Adjusted B (95% CI) | Adjusted P | B (95% CI) | P | Adjusted B (95% CI) | Adjusted P | B (95% CI) | P | Adjusted B (95% CI) | Adjusted P | |
Age (≥ 25 vs < 25 years) | 4.26 (1.15, 7.36) | 0.008 | 4.09 (0.94, 7.24) | 0.011 | 5.47 (−0.99, 11.93) | 0.097 | 5.76 (− 0.52, 12.04) | 0.072 | 0.11 (− 0.36, 0.58) | 0.635 | 0.09 (− 0.42, 0.59) | 0.729 |
Gender (Male ve Female) | 2.35 (− 0.6, 5.3) | 0.118 | 2.38 (− 0.55, 5.31) | 0.110 | 5.48 (− 0.55, 11.52) | 0.075 | 6.42 (0.57, 12.26) | 0.032 | 0.22 (−0.22, 0.65) | 0.334 | 0.13 (−0.34, 0.6) | 0.586 |
Family History (Yes vs No) | 0.56 (−2.14, 3.26) | 0.684 | 0.55 (− 2.41, 3.51) | 0.714 | 1.96 (−3.57, 7.48) | 0.485 | 0.03 (−5.87, 5.94) | 0.991 | 0.01 (−0.38, 0.41) | 0.943 | −0.03 (− 0.5, 0.44) | 0.903 |
Vertical Transmission (Yes vs No) | −1.34 (−5, 2.33) | 0.472 | − 1.42 (− 5.41, 2.57) | 0.483 | 2.05 (− 5.47, 9.57) | 0.591 | 1.00 (−6.96, 8.97) | 0.804 | −0.01 (− 0.56, 0.53) | 0.961 | − 0.03 (− 0.67, 0.61) | 0.931 |
Infection Time (≥ 20 vs < 20 years) | −0.2 (−4.01, 3.6) | 0.917 | −1.88 (− 5.74, 1.98) | 0.336 | 0.85 (− 6.95, 8.64) | 0.831 | − 1.49 (−9.19, 6.2) | 0.702 | − 0.08 (− 0.65, 0.48) | 0.769 | −0.16 (− 0.77, 0.46) | 0.616 |
Log HBsAg | 0.60 (− 1.54, 2.75) | 0.577 | 0.79 (− 1.35, 2.93) | 0.466 | 0.004 (− 4.39–4.40) | 0.999 | 0.42 (− 3.85, 4.68) | 0.848 | 0.08 (− 0.24, 0.40) | 0.621 | 0.01 (− 0.33, 0.36) | 0.938 |
Log HBV DNA | 0.09 (−0.45, 0.63) | 0.741 | −0.99 (− 2.09, 0.11) | 0.078 | 1.45 (0.36–2.54) | 0.010 | −0.74 (− 2.94, 1.45) | 0.505 | 0.26 (− 0.2, 0.72) | 0.260 | − 0.06 (− 0.24, 0.11) | 0.483 |
HBeAg (Positive vs Negative) | 1.18 (− 1.51, 3.87) | 0.387 | 4.30 (− 0.10, 8.70) | 0.055 | 7.18 (1.77, 12.58) | 0.010 | 8.25 (−0.53, 17.03) | 0.065 | −0.22 (− 0.62, 0.17) | 0.266 | − 0.01 (− 0.72, 0.69) | 0.969 |
ALT (< 2 ULN is the reference group) | ||||||||||||
≥ 2 & < 5 ULN | 6.16 (2.76, 9.56) | 0.000 | 6.77 (3.08, 10.46) | 0.000 | 14.41 (7.64, 21.19) | 0.000 | 13.08 (5.72, 20.44) | 0.001 | −0.14 (− 0.67, 0.38) | 0.594 | − 0.05 (− 0.64, 0.54) | 0.859 |
≥ 5ULN | 3.89 (− 0.34, 8.12) | 0.072 | 3.82 (− 0.79, 8.44) | 0.104 | 13.2 (4.77, 21.64) | 0.002 | 9.08 (−0.12, 18.29) | 0.053 | 0.20 (−0.45, 0.86) | 0.539 | 0.23 (−0.51, 0.97) | 0.533 |
Genotype (Genotype C is the reference group) | ||||||||||||
B | −0.84 (−4.2, 2.53) | 0.623 | −0.14 (−3.42, 3.13) | 0.930 | −4.03 (−10.79, 2.73) | 0.241 | −2.5 (−9.04, 4.04) | 0.451 | − 0.52 (− 1.02, − 0.03) | 0.039 | −0.49 (− 1.02, 0.03) | 0.067 |
N | −0.85 (−5.43, 3.73) | 0.715 | − 2.39 (−7.83, 3.06) | 0.388 | − 9.19 (− 18.39, 0.01) | 0.050 | −6.88 (− 17.75, 3.99) | 0.213 | − 0.36 (− 1.04, 0.31) | 0.288 | − 0.59 (− 1.46, 0.28) | 0.184 |
O | −5.27 (− 10.98, 0.45) | 0.071 | −3.46 (− 9.08, 2.17) | 0.226 | −16.2 (− 27.68, − 4.72) | 0.006 | −11.84 (− 23.06, − 0.63) | 0.039 | − 0.68 (− 1.52, 0.16) | 0.113 | − 0.64 (− 1.54, 0.26) | 0.161 |