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Table 1 Clinical-virological characteristics of patients included in the study

From: Association among cytokine profiles of innate and adaptive immune responses and clinical-virological features in untreated patients with chronic hepatitis B

Characteristics IT (n = 17) IA (n = 120) IC (n = 20) GZ (n = 72) HC (n = 17) P value
Age, years, median (quartile) 25 (24, 26) 29 (25, 33.25) 32 (28.75, 37) 31.5 (26, 38.25) 27 (25.5, 36) <  0.001
Gender       0.238
 Male, n (%) 12 (70.6) 77 (64.2) 17 (85) 55 (76.4) 12 (70.6)  
 Female, n (%) 5 (29.4) 43 (35.8) 3 (15) 17 (23.6) 5 (29.4)  
ALT, U/L, median (quartile) 20.6 (18.3, 22.4) 20.8 (19.1, 22.5) 22.3 (21.6, 23.8) 21.484 (19.8, 23.4) 16 (12.5, 22.0)) < 0.001
Fibroscan, Kpa median (quartile) 4.9 (4.2, 5.4) 5.3 (4.3, 6.5) 4.4 (4.0, 5.3) 4.8 (4.4, 5.4) 4.6 (4.0 ~ 5.1) 0.016
HBV DNA, Log IU/ml, median (quartile) 8.2 (8.2, 8.2) 7.7 (5.0, 8.2) 2.2 (1.6, 3.1) 3.3 (2.1, 4.3)   < 0.001
HBeAg status       <  0.001
 Negative, n (%) 0 (0) 41 (34) 20 (100) 62 (86)   
 Positive, n (%) 17 (100) 78 (65) 0 (0) 10 (14)   
 Missing, n (%) 0 (0) 1 (1) 0 (0) 0 (0)   
HBeAb status       <  0.001
 Negative, n (%) 17 (100) 70 (58.3) 1 (5) 13 (18.1)   
 Positive, n (%) 0 (0) 47 (39.2) 19 (95) 59 (81.9)   
 Missing, n (%) 0 (0) 3 (2.5) 0 (0) 0 (0)   
qHBsAg, Log IU/ml, median (quartile) 4.6 (4.5, 4.7) 4.0 (3.3, 4.7) 2.9 (2.0, 3.2) 3.2 (2.3, 3.6)   <  0.001
HBsAb status       <  0.001
 Negative, n (%) 15 (88) 106 (88) 20 (100) 67 (93)   
 Positive, n (%) 2 (12) 14 (12) 0 (0) 5 (7)   
HBV genotype       <  0.001
 C, n(%) 2 (12) 30 (25) 3 (15) 15 (21)   
 B, n (%) 12 (71) 74 (62) 8 (40) 27 (38)   
 N, n (%) 0 (0) 2 (2) 9 (45) 23 (32)   
 O, n (%) 1 (6) 8 (1) 0 (0) 23 (32)   
 Missing, n(%) 2 (11) 6 (5) 0 (0) 1 (1)   
  1. HBV genotype: Other included C + D, B + D, B + C, D; N, not detected
  2. IT immune tolerant, IA immune active, IC inactive carrier, GZ gray zones, ALT alanine aminotransferase, HBeAb antibody to HBV e antigen, HBeAg, HBV e antigen, HBsAb antibody to hepatitis B surface antigen, qHBsAg quantitative hepatitis B surface antigen;