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Table 3 Outcomes by baseline urine-LAM status among patients not on anti-TB treatment at study entry (n = 468)

From: Determine TB-LAM point-of-care tuberculosis assay predicts poor outcomes in outpatients during their first year of antiretroviral therapy in South Africa

 

All patients

(n = 468)

LAM positive

(n = 38)

LAM Negative/TB diagnosed

(n = 111)

LAM Negative/No TB diagnosed

(n = 319)

p-value

Clinical outcome at three months

 Required hospitalization

50 (10.7)

10 (26.3)

20 (18.0)

20 (6.3)

< 0.001

 Hospital readmission

4 (0.9)

0

2 (1.8)

2 (0.6)

0.48

 Vital status

  Dead

31 (6.6)

11 (29.0)

6 (5.4)

14 (4.4)

< 0.001

  LTFU

2 (0.4)

0

0

2 (0.6)

 

  Alive

435 (93.0)

27 (71.1)

105 (94.6)

303 (95.0)

 

Clinical outcome at  six months

 Required hospitalization

73 (15.6)

16 (42.1)

29 (26.1)

28 (8.8)

< 0.001

 Hospital readmission

6 (1.3)

1 (2.6)

3 (2.7)

2 (0.6)

0.14

 Vital status

  Dead

44 (9.4)

12 (31.6)

11 (9.9)

21 (6.6)

< 0.001

  LTFU

2 (0.4)

0

0

2 (0.6)

 

  Alive

422 (90.2)

26 (68.4)

100 (90.1)

296 (92.8)

 

Clinical outcome at one year

 Required hospitalization

84 (18.0)

17 (44.7)

36 (32.4)

31 (9.7)

< 0.001

 Median time to hospitalization (IQR), (median [IQR] in days)a

39 (13–129)

18 (4–118)

74 (14–166)

31 (14–149)

0.39

 Hospital readmission

10 (2.1)

1 (2.6)

5 (4.5)

4 (1.3)

0.10

 Vital status

  Dead

57 (12.2)

12 (31.6)

17 (15.3)

28 (8.8)

0.002

  LTFU

7 (1.5)

0

1 (0.9)

6 (1.9)

 

  Alive

404 (86.3)

26 (68.4)

93 (83.8)

285 (89.3)

 

 Median time to death (IQR), (median [IQR] in days)b

74 (25–140)

19 (8–65)

124 (38–259)

90 (27–160)

0.002

 Died without starting TB treatment (among all patients)

35 (7.5)

5 (13.2)

2 (1.8)

28 (8.8)

0.021

  1. Abbreviations: LTFU lost-to-follow-up
  2. an = 84; bn = 57