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Table 1 Case reports of invasive fungal infections due to Conidiobolus spp.

From: Conidiobolus pachyzygosporus invasive pulmonary infection in a patient with acute myeloid leukemia: case report and review of the literature

Year of publication, region/country (reference) Underlying conditions Organs affected Species Treatment (dose), duration and outcome
1970, West Virginia (USA)
[7, 10]
1 year-old male, no underlying conditions Mediastinum, lungs, pericardium C. incongruus Deoxycholate amphotericin B (1 mg/kg/day), 10 weeks
Outcome: cure
1983, Thailand
[5]
20 year-old female, no underlying conditions Soft tissues (breast), lungs, mediastinum, liver, gastro-intestinal tract C. incongruus Co-trimoxazole (2 g/day), duration NS
Outcome: death
1990, Texas (USA)
[8]
29 year-old male, cocaine abuse Endocardium, blood, skin, heart, lungs, kidneys, brain, muscles Conidiobolus spp. None
Outcome: death
1992, Mississippi (USA)
[12]
64 year-old male, kidney transplantation Lungs, myocardium, brain, kidney, thyroid C. coronatus Deoxycholate amphotericin B (50 mg every other day), until death
Outcome: death
1994, Maryland (USA)
[13]
32 year-old female, lymphocytic lymphoma with leukemic transformation (neutropenia) Lungs, pericardium C. incongruus Deoxycholate amphotericin B (0.5 mg/kg/day, then 1.5 mg/kg/day) and flucytosine (150 mg/kg/day), until death
Surgery
Outcome: death
2009, India
[11]
10 year-old female, T-cell acute lymphoblastic leukemia Sinus, soft tissues (facial) C. coronatus Amphotericin B (NS), until death
Surgery
Outcome: death
2010, Germany
[14]
78 year-old female, myelodysplastic syndrome Sinus, soft tissues (facial), brain C. incongruus Liposomal amphotericin B (200 mg/day), until death
Surgery
Outcome: death
2011, Japan
[9]
61 year-old male, mantle cell lymphoma, allogeneic HSCT Lungs, heart, spleen, kidney, bladder, thyroid C. lamprauges Micafungin (150 mg/day) and liposomal amphotericin B (2.5 mg/kg/day), then intravenous voriconazole (6 mg/kg/day on day 1, then 4 mg/kg/day) and micafungin (150 mg/day), until death
Outcome: death
2018, Wisconsin (USA)
[6]
15 year-old male, B-cell lymphoblastic leukemia (neutropenia) Sinus, lungs C. coronatus Liposomal amphotericin B (10 mg/kg/day) and anidulafungin (1.5 mg/kg/day) and oral terbinafine (250 mg twice per day), duration NS
Surgery, granulocyte transfusion
Outcome: cure
2019, Switzerland
(present case)
71 year-old, acute myeloid leukemia (neutropenia) Lungs Conidiobolus spp. Caspofungin (70 mg/day on day 1, then 50 mg/day), then liposomal amphotericin B (5 mg/kg/day), then oral isavuconazole (200 mg three times per day on day 1 and 2, then 200 mg/day), 2 months
Surgery
Outcome: cure
  1. NS Not specified