Category

SMA (n = 137)

NonSMA (n = 437)

P Value^{a}

OR

95% CI

PValue^{b}


Coinheritance of Haemoglobin and G6PD deficiency

SMA

AA/Normal

69 (50.4)

230 (52.6)

0.003

Ref

–

–

AA/Deficient

1 (0.7)

9 (2.1)

0.370

0.046–2.975

0.350

AA/Intermediate

53 (38.7)

115 (26.3)

1.536

1.007–2.343

0.046

AS/Deficient

0 (0.0)

3 (0.7)

xx

xx

xx

AS/Intermediate

5 (3.6)

26 (5.9)

0.641

0.237–1.732

0.381

AS/Normal

6 (4.4)

53 (12.1)

0.377

0.156–0.915

0.031

SS/Intermediate

1 (0.7)

1 (0.7)

XX

XX

XX

SS/Normal

2 (1.5)

0 (0.0)

XX

XX

XX

 Data shown are number (n) and proportions (%) of subjects. ^{a}Statistical comparison was performed using Pearson’s Chisquare test. Odds ratios (OR) and 95% confidence intervals (95% CI) were determined using multivariate logistic regression controlling for age and sex. SMA, severe malaria anaemia, nonsevere malaria anaemia. AA, normal hemoglobin. AS, heterozygote sickle cell. SS, homozygote sickle cell. XX, multivariate logistic regression was not performed because the numbers were too few to run in the model