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Table 5 Influence of co-inheritance of haemoglobin and G6PD genotypes on P. falciparum infection in children under 3 years in Vihiga County, Kenya

From: Influence of blood group, Glucose-6-phosphate dehydrogenase and Haemoglobin genotype on Falciparum malaria in children in Vihiga highland of Western Kenya

Category SMA (n = 137) Non-SMA (n = 437) P- Valuea OR 95% CI P-Valueb
Co-inheritance of Haemoglobin and G6PD deficiency SMA
AA/Normal 69 (50.4) 230 (52.6) 0.003 Ref
AA/Deficient 1 (0.7) 9 (2.1) 0.370 0.046–2.975 0.350
AA/Intermediate 53 (38.7) 115 (26.3) 1.536 1.007–2.343 0.046
AS/Deficient 0 (0.0) 3 (0.7) xx xx xx
AS/Intermediate 5 (3.6) 26 (5.9) 0.641 0.237–1.732 0.381
AS/Normal 6 (4.4) 53 (12.1) 0.377 0.156–0.915 0.031
SS/Intermediate 1 (0.7) 1 (0.7) XX XX XX
SS/Normal 2 (1.5) 0 (0.0) XX XX XX
  1. Data shown are number (n) and proportions (%) of subjects. aStatistical comparison was performed using Pearson’s Chi-square test. Odds ratios (OR) and 95% confidence intervals (95% CI) were determined using multivariate logistic regression controlling for age and sex. SMA, severe malaria anaemia, non-severe malaria anaemia. AA, normal hemoglobin. AS, heterozygote sickle cell. SS, homozygote sickle cell. XX, multivariate logistic regression was not performed because the numbers were too few to run in the model