Fig. 4

Quantities of vaginal bacterial species in the SOC and intervention group. a Bacterial species contained in the administered probiotic, including L. acidophilus, L. rhamnosus, B. bifidum and B. longum, vaginal Lactobacillus spp., including L. crispatus, L. gasseri, L. jensenii, L. vaginalis, L. mucosae and L. iners (b) and BV-associated bacteria, including G. vaginalis, P bivia, Atopobium, BVAB2 and Megasphera (c) were measured by qPCR and normalised to total 16S rRNA gene concentration at month 0 (enrolment) and 1, 3 and 5 months post-treatment. Values were log-transformed and supervised clustering was used to generate the heatmap. Each row shows one participant. Darkest blue indicates levels below detection limit. White data points indicate missing data. Light purple indicates participants from the SOC and dark purple participants from the intervention group