Fig. 3

ROC-curves for RpfB and RpfD in an IGRA-based screening for MTBC infection. IGRA+ participants were classified as infected and IGRA- participants were classified as uninfected. AUC’s for RpfB and D are 0.77 and 0.74, respectively. Cut-off values for IFN-γ levels were based on the Youden Index. For RpfB, a cut-off at 33.9 pg/mL led to 73% sensitivity and 92% specificity. For RpfD, a cut-off of 67.0 pg/mL led to 77% sensitivity and 72% specificity. ROC: Receiver operating curve; Rpf: Resuscitation promoting factor; IGRA (interferon gamma release assay); AUC: area under the curve