Fig. 2

IFN-γ response after ex vivo whole blood antigen stimulation. The first panel (a) “medium” depicts the results of the unstimulated assays, i.e., the background level. The other panels (b-h) represent the respective antigen-stimulated assays. Solid lines: median IFN- γ values per infection category. IFN-γ concentrations were corrected for the background signal (value of unstimulated IFN-γ level subtracted), except for the results in the first panel “medium”. All values above 4000 were set to 4000 pg/mL. P-values below 0.05 indicated. P-values were derived from logistic regression models including possible confounders age and sex, after log-transformation of the IFN-γ variable. IGRA: IFN-γ release assay; EC: Esat-6/CFP-10; PPD: Purified protein derivative; Rpf: Resuscitation promoting factor