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Table 1 Antimicrobial susceptibility profile of coagulase-negative Staphylococcus sp. (CoNS) isolates in asymptomatic and symptomatic central line-associated bloodstream infections

From: Asymptomatic central line-associated bloodstream infections in children implanted with long term indwelling central venous catheters in a teaching hospital, Sri Lanka

Antibiotic CLABSI P value
Symptomatic- CoNS Asymptomatic- CoNS
S. epidermidis (n = 10) S. hemolyticus (n = 6) S. epidermidis (n = 54) S. hemolyticus (n = 6) S. schleiferi (n = 5) S. lugdunensis (n = 5)
Ampicillin (30 μg) 2 (20%) 1 (17%) 47 (87.3%) * 6 (100%) 5 (100%) 5 (100%) 0.03*
Cefoxitin (30 μg) 2 (20%) 1 (17%) 45 (85.7%) ** 6 (100%) 5 (100%) 5 (100%) 0.02**
Oxacillin 2 (20%) 1 (17%) 45 (85.7%) *** 6 (100%) 5 (100%) 5 (100%) 0.03***
Ciprofloxacin (5 μg) 1 (10%) 1 (17%) 45 (85.7%) α 4 (67%) 5 (100%) 5 (100%) 0.03α
Levofloxacin (5 μg) 2 (20%) 1 (17%) 45 (85.7%) μ 4 (67%) 4 (80%) 5 (100%) 0.03μ
Trimethoprim/ sulfamethoxazole (1.25/23.25 μg) 1 (10%) 1 (17%) 42 (79.3%) 4 (67%) 5 (100%) 5 (100%) 0.03
Amikacin (30 μg) 3 (30) 1 (17%) 42 (79.3%) 4 (67%) 5 (100%) 5 (100%) 0.03
Gentamicin (10 μg) 2 (20) 1 (17%) 42 (79.3%) 4 (67%) 5 (100%) 5 (100%) 0.03
Erythromycin (30 μg) 2 (20) 1 (17%) 42 (79.3%) 4 (67%) 5 (100%) 5 (100%) 0.03
Clindamycin (30 μg) 2 (20) 1 (17%) 42 (79.3%) 4 (67%) 5 (100%) 5 (100%) 0.03
vancomycin 0 0 0 0 0 0
Linezolid 0 0 0 0 0 0
Tigecycline 0 0 0 0 0 0
  1. P < 0.05 taken as significant
  2. * Ampicillin resistance is significantly low in S. epidermidis; ** Cefoxitin resistance is significantly low in S. epidermidis; *** Oxacillin resistance is significantly low in S. epidermidis; α Ciprofloxacin resistance is significantly low in S. epidermidis; μ Levofloxacin resistance is significantly low in S. epidermidis