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Table 6 Algorithms for predicting TB among contacts based on cytokine CF responses and clinical symptoms. A. Co-prevalent TBa versus Not TBa

From: Predictive value of TNF-α, IFN-γ, and IL-10 for tuberculosis among recently exposed contacts in the United States and Canada

Characteristics

Sensitivity (%)

Specificity (%)

PPVb (%) (CI)b

NPVb (%)

ALL (41 co-prevalent TB, 1212 not TB)a

 TNF > Median

71

49

5 (3,7)

98

 INF > Median

79

51

5 (4,7)

99

 IL10 > Median

59

50

4 (2,6)

97

 All > Median

37

80

6 (3,9)

97

 Any > Median

90

22

4 (3,5)

98

 TST-

0

49

0

100

 Initial TST+

88

59

7 (5,9)

99

 Converter

2

92

1 (0,7)

96

 TST+/Converter

100

51

6 (5,9)

100

 Age < 15 years

17

89

5 (2,11)

97

 Age > = 15 years

83

11

3 (2,4)

 

TST+/Converter (41 co-prevalent TB, 595 not TB)a

 TNF > Median

51

51

7 (4,10)

94

 INF > Median

69

50

9 (6,12)

96

 IL10 > Median

59

51

7 (6,11)

95

 All > Median

29

80

9 (5,15)

94

 Any > Median

83

22

7 (5,10)

95

TST+/Converter and age < 15 years (7 co-prevalent TB, 33 not TB)a

 TNF > Median

43

52

16 (4,40)

81

 INF > Median

50

53

17 (4,42)

100

 IL10 > Median

43

53

17 (4,42)

81

 All > Median

29

91

40 (7,83)

86

 Any > Median

57

18

13 (4,31)

67

TST+/Converter and age > = 15 years (34 co-prevalent TB, 562 not TB)a

 TNF > Median

53

51

6 (4,10)

95

 INF > Median

70

50

8 (5,12)

96

 IL10 > Median

59

51

6 (4,10)

96

 All > Median

26

79

7 (3,13)

95

 Any > Median

85

22

6 (4,9)

96

Contacts with Cough (23 co-prevalent TB, 148 not TB)a

 TNF > Median

83

53

22 (14,32)

95

 INF > Median

86

51

21 (13,31)

96

 IL10 > Median

52

50

13 (7,23)

88

 All > Median

30

81

20 (9,37)

88

 Any > Median

100

22

17 (11,24)

100

Contacts with Fever or Weight Loss (21 co-prevalent TB, 68 not TB)a

 TNF > Median

81

53

35 (23,51)

90

 INF > Median

100

52

38 (26,53)

100

 IL10 > Median

65

51

28 (16,44)

83

 All > Median

43

85

47 (25,71)

83

 Any > Median

100

19

28 (18,39)

100

Contacts with Immune Compromising Conditions (34 co-prevalent TB, 844 not TB)a

 TNF > Median

76

51

6 (4,9)

98

 INF > Median

85

51

7 (4,9)

99

 IL10 > Median

62

51

5 (3,7)

97

 All > Median

44

80

8 (5,13)

97

 Any > Median

94

121

5 (3,6)

99

  1. aThe number of contacts included varies slightly from the numbers presented in the subheading for some characteristics because 14 contacts were missing TNF results (all 14 not TB), 38 contacts were missing IFN results (2 co-prevalent TB and 36 not TB), and 23 contacts were missing IL10 results (2 co-prevalent TB and 21 not TB)
  2. bCo-prevalent TB defined as TB diagnosis before or < 30 days after blood draw; TNF-α Tumor necrosis factor alpha, TST tuberculin skin test, TB tuberculosis, Immune Compromising Conditions = diabetes, kidney failure, cancer, chemotherapy, organ transplant, or current steroid use; CF culture filtrate, PPV positive predictive value, NPV negative predictive value, CI confidence interval
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BMC Infectious Diseases

ISSN: 1471-2334

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